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Literature DB >> 16855688

A convergent synthesis of new beta-turn mimics by click chemistry.

Abstract

Alkyne-azide cycloaddition ("click" chemistry) between two peptide strands derivatized with terminal azide and alkyne, respectively, provides an efficient convergent synthesis of triazole ring-based new beta-turn mimics.

Entities: Chemical

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Year: 2006 PMID： 16855688 DOI： 10.1039/b606185k

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

15 in total

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Authors: Laura E Hanold; Christopher P Watkins; Norman T Ton; Peter Liaw; Aaron M Beedle; Eileen J Kennedy
Journal: Bioorg Med Chem Date: 2015-03-20 Impact factor: 3.641

2. Exploration of inhibitors of the bacterial LexA repressor-protease.

Authors: Ana Victoria Cheng Jaramillo; Michael B Cory; Allen Li; Rahul M Kohli; William M Wuest
Journal: Bioorg Med Chem Lett Date: 2022-03-26 Impact factor: 2.940

3. Protein prosthesis: 1,5-disubstituted[1,2,3]triazoles as cis-peptide bond surrogates.

Authors: Annie Tam; Ulrich Arnold; Matthew B Soellner; Ronald T Raines
Journal: J Am Chem Soc Date: 2007-10-03 Impact factor: 15.419

4. Peptide tertiary structure nucleation by side-chain crosslinking with metal complexation and double "click" cycloaddition.

Authors: Oscar Torres; Deniz Yüksel; Matt Bernardina; Krishna Kumar; Dennis Bong
Journal: Chembiochem Date: 2008-07-21 Impact factor: 3.164

A convergent synthesis of new beta-turn mimics by click chemistry.

1. Design of a selenylsulfide-bridged EGFR dimerization arm mimic.

2. Exploration of inhibitors of the bacterial LexA repressor-protease.

3. Protein prosthesis: 1,5-disubstituted[1,2,3]triazoles as cis-peptide bond surrogates.

4. Peptide tertiary structure nucleation by side-chain crosslinking with metal complexation and double "click" cycloaddition.

5. Cycloaddition-promoted self-assembly of a polymer into well-defined beta sheets and hierarchical nanofibrils.

Review 6. Artificial beta-sheets: chemical models of beta-sheets.

Review 7. Tailored therapeutics based on 1,2,3-1H-triazoles: a mini review.

8. Inhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimics.

Review 9. 1,2,3-Triazoles as Biomimetics in Peptide Science.

10. Synthesis of new triazole-based trifluoromethyl scaffolds.