| Literature DB >> 16854585 |
Su Yeon Kim, Eun-Jeong Yoon, Eung-Chil Choi, Sunghoon Kim, Taehee Kang, Farhana Samrin, Sadhna Puri, Jeewoo Lee.
Abstract
Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.Entities:
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Year: 2006 PMID： 16854585 DOI： 10.1016/j.bmc.2006.06.062
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641