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Literature DB >> 16854568

Biological roles of the Lon ATP-dependent protease.

Virginie Tsilibaris¹, Geneviève Maenhaut-Michel, Laurence Van Melderen.

Abstract

The Lon ATP-dependent protease plays a major role in protein quality control. An increasing number of regulatory proteins, however, are being identified as Lon substrates, thus indicating that in addition to its housekeeping function, Lon plays an important role in regulating many biological processes in bacteria. This review presents and discusses the involvement of Lon in different aspects of bacterial physiology, including cell differentiation, sporulation, pathogenicity and survival under starvation conditions.

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Year: 2006 PMID： 16854568 DOI： 10.1016/j.resmic.2006.05.004

Source DB: PubMed Journal: Res Microbiol ISSN： 0923-2508 Impact factor: 3.992

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Cited

77 in total

1. An alternative flexible conformation of the E. coli HUβ₂ protein: structural, dynamics, and functional aspects.

Authors: Norbert Garnier; Karine Loth; Franck Coste; Rafal Augustyniak; Virginie Nadan; Christian Damblon; Bertrand Castaing
Journal: Eur Biophys J Date: 2010-10-10 Impact factor: 1.733

2. Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.

Authors: Samer Sakr; Anne-Marie Cirinesi; Ronald S Ullers; Françoise Schwager; Costa Georgopoulos; Pierre Genevaux
Journal: J Biol Chem Date: 2010-05-26 Impact factor: 5.157

3. Oxidization without substrate unfolding triggers proteolysis of the peroxide-sensor, PerR.

Authors: Bo-Eun Ahn; Tania A Baker
Journal: Proc Natl Acad Sci U S A Date: 2015-12-17 Impact factor: 11.205

4. Microbial metabolic potential for carbon degradation and nutrient (nitrogen and phosphorus) acquisition in an ombrotrophic peatland.

Authors: Xueju Lin; Malak M Tfaily; Stefan J Green; J Megan Steinweg; Patrick Chanton; Aopeau Imvittaya; Jeffrey P Chanton; William Cooper; Christopher Schadt; Joel E Kostka
Journal: Appl Environ Microbiol Date: 2014-03-28 Impact factor: 4.792

Biological roles of the Lon ATP-dependent protease.

1. An alternative flexible conformation of the E. coli HUβ₂ protein: structural, dynamics, and functional aspects.

2. Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.

3. Oxidization without substrate unfolding triggers proteolysis of the peroxide-sensor, PerR.

4. Microbial metabolic potential for carbon degradation and nutrient (nitrogen and phosphorus) acquisition in an ombrotrophic peatland.

5. Lon protease is essential for paradoxical survival of Escherichia coli exposed to high concentrations of quinolone.

6. Recognition of misfolded proteins by Lon, a AAA(+) protease.

7. Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease.

8. Identification of Burkholderia cenocepacia strain H111 virulence factors using nonmammalian infection hosts.

9. Overproduction of exopolysaccharides by an Escherichia coli K-12 rpoS mutant in response to osmotic stress.

10. Binding and cleavage of E. coli HUbeta by the E. coli Lon protease.