Literature DB >> 1685144

Human CD2 is functional in CD2 transgenic mice.

E Monostori1, G Lang, D Kioussis, D A Cantrell, R Zamoyska, M H Brown, M J Crumpton.   

Abstract

We aimed to study the biochemical consequences of T-cell activation via the CD2 antigen in mouse T cells. The lack of stimulatory monoclonal antibodies against the mouse CD2 antigen led us to analyse this problem in transgenic mice carrying and expressing the human CD2 gene. Monoclonal antibodies to the human CD2 antigen that were mitogenic for human T cells induced proliferation of mouse T cells from the CD2 transgenic mice. Stimulation was accompanied by rapid phosphorylation of the murine CD3 gamma chain and T-cell receptor zeta chain. These results demonstrate that the human CD2 antigen is functional in the CD2 transgenic mice and indicate a considerable conservation of the signal transducing processes and also the activation mechanisms between mouse and man.

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Year:  1991        PMID： 1685144      PMCID： PMC1384626     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  24 in total

1.  High resolution two-dimensional electrophoresis of basic as well as acidic proteins.

Authors:  P Z O'Farrell; H M Goodman; P H O'Farrell
Journal:  Cell       Date:  1977-12       Impact factor: 41.582

Review 2.  Human T-cell precursors: involvement of the IL-2 pathway in the generation of mature T cells.

Authors:  M L Toribio; J M Alonso; A Bárcena; J C Gutiérrez; A de la Hera; M A Marcos; C Márquez; C Martínez
Journal:  Immunol Rev       Date:  1988-08       Impact factor: 12.988

3.  The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression.

Authors:  W A Sewell; M H Brown; M J Owen; P J Fink; C A Kozak; M J Crumpton
Journal:  Eur J Immunol       Date:  1987-07       Impact factor: 5.532

4.  Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.

Authors:  H Yagita; T Nakamura; H Karasuyama; K Okumura
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

5.  Stable expression of the cDNA encoding the human T lymphocyte-specific CD2 antigen in murine L cells.

Authors:  N A Clipstone; M J Crumpton
Journal:  Eur J Immunol       Date:  1988-10       Impact factor: 5.532

6.  The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.

Authors:  M Baniyash; P Garcia-Morales; E Luong; L E Samelson; R D Klausner
Journal:  J Biol Chem       Date:  1988-12-05       Impact factor: 5.157

7.  Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.

Authors:  S M Denning; D T Tuck; L W Vollger; T A Springer; K H Singer; B F Haynes
Journal:  J Immunol       Date:  1987-10-15       Impact factor: 5.422

8.  The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.

Authors:  L K Bockenstedt; M A Goldsmith; M Dustin; D Olive; T A Springer; A Weiss
Journal:  J Immunol       Date:  1988-09-15       Impact factor: 5.422

9.  Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).

Authors:  M L Plunkett; M E Sanders; P Selvaraj; M L Dustin; T A Springer
Journal:  J Exp Med       Date:  1987-03-01       Impact factor: 14.307

10.  Similarities in sequences and cellular expression between rat CD2 and CD4 antigens.

Authors:  A F Williams; A N Barclay; S J Clark; D J Paterson; A C Willis
Journal:  J Exp Med       Date:  1987-02-01       Impact factor: 14.307
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  1 in total

Review 1.  Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets.

Authors:  Peter J Bugelski; Pauline L Martin
Journal:  Br J Pharmacol       Date:  2012-06       Impact factor: 8.739
  1 in total

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