Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis.

Literature DB >> 16850186

Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis.

Guangming Ye¹, Cong Chen, Dingding Han, Xiabin Xiong, Yahui Kong, Bo Wan, Long Yu.

Abstract

The Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. Here we report the cloning and characterization of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene, which was mapped to human chromosome 4p24. This cDNA is 1859 bp in length, encoding a putative protein of 515 amino acids. The NHEDC1 proteins are highly conserved in mammals including human, mouse, rat, and Macaca fascicularis. One remarkable characteristic of human NHEDC1 gene is that it is exclusively expressed in the testis by RT-PCR analysis. Western blot analysis showed that the molecular weight of NHEDC1 is about 56 KDa.

Entities: Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16850186 DOI： 10.1007/s11033-006-0010-y

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

18 in total

Review 1. The expanding family of eucaryotic Na(+)/H(+) exchangers.

Authors: L Counillon; J Pouysségur
Journal: J Biol Chem Date: 2000-01-07 Impact factor: 5.157

2. Overexpression of a plasma membrane Na+/H+ antiporter gene improves salt tolerance in Arabidopsis thaliana.

Authors: Huazhong Shi; Byeong-ha Lee; Shaw-Jye Wu; Jian-Kang Zhu
Journal: Nat Biotechnol Date: 2002-12-09 Impact factor: 54.908

3. The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".

Authors: S Wakabayashi; P Fafournoux; C Sardet; J Pouysségur
Journal: Proc Natl Acad Sci U S A Date: 1992-03-15 Impact factor: 11.205

4. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

Authors: J Orlowski; R A Kandasamy; G E Shull
Journal: J Biol Chem Date: 1992-05-05 Impact factor: 5.157

5. Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2).

Authors: J F Collins; T Honda; S Knobel; N M Bulus; J Conary; R DuBois; F K Ghishan
Journal: Proc Natl Acad Sci U S A Date: 1993-05-01 Impact factor: 11.205

Review 6. Na+/H+ exchangers of mammalian cells.

Authors: J Orlowski; S Grinstein
Journal: J Biol Chem Date: 1997-09-05 Impact factor: 5.157

Review 7. Kinetic properties of the plasma membrane Na+-H+ exchanger.

Authors: P S Aronson
Journal: Annu Rev Physiol Date: 1985 Impact factor: 19.318

8. Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

Authors: C Sardet; A Franchi; J Pouysségur
Journal: Cell Date: 1989-01-27 Impact factor: 41.582

9. A NHE3-related pseudogene is on human Chromosome 10; the functional gene maps to 5pl5.3.

Authors: F T Kokke; T Elsawy; U Bengtsson; J J Wasmuth; E Wang Jabs; C M Tse; M Donowitz; S R Brant
Journal: Mamm Genome Date: 1996-03 Impact factor: 2.957

10. A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility.

Authors: Dan Wang; Shelby M King; Timothy A Quill; Lynda K Doolittle; David L Garbers
Journal: Nat Cell Biol Date: 2003-11-23 Impact factor: 28.824

12 in total

Review 1. Na(+)/H(+) exchange and hypoxic pulmonary hypertension.

Authors: John Huetsch; Larissa A Shimoda
Journal: Pulm Circ Date: 2015-06 Impact factor: 3.017

Review 2. Traditional and emerging roles for the SLC9 Na+/H+ exchangers.

Authors: Daniel G Fuster; R Todd Alexander
Journal: Pflugers Arch Date: 2013-12-12 Impact factor: 3.657

Review 3. Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule.

Authors: Mark D Parker; Evan J Myers; Jeffrey R Schelling
Journal: Cell Mol Life Sci Date: 2015-02-14 Impact factor: 9.261

4. SLC9B1 methylation predicts fetal intolerance of labor.

Authors: Anna K Knight; Karen N Conneely; Varun Kilaru; Dawayland Cobb; Jennifer L Payne; Samantha Meilman; Elizabeth J Corwin; Zachary A Kaminsky; Anne L Dunlop; Alicia K Smith
Journal: Epigenetics Date: 2018-01-25 Impact factor: 4.528

5. Identification and characterization of methylation-dependent/independent DNA regulatory elements in the human SLC9B1 gene.

Authors: Priya L Kumar; Paul F James
Journal: Gene Date: 2015-02-19 Impact factor: 3.688

6. Evolution of Vertebrate Solute Carrier Family 9B Genes and Proteins (SLC9B): Evidence for a Marsupial Origin for Testis Specific SLC9B1 from an Ancestral Vertebrate SLC9B2 Gene.

Authors: Roger S Holmes; Kimberly D Spradling-Reeves; Laura A Cox
Journal: J Phylogenetics Evol Biol Date: 2016-06-10

10. Comparative genomic analysis suggests that the sperm-specific sodium/proton exchanger and soluble adenylyl cyclase are key regulators of CatSper among the Metazoa.

Authors: Francisco Romero; Takuya Nishigaki
Journal: Zoological Lett Date: 2019-07-26 Impact factor: 2.836