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Literature DB >> 16846804

The impact of interferon-beta treatment on the blood-brain barrier.

Abstract

Changes in the blood-brain barrier (BBB) are crucial to the pathogenesis of multiple sclerosis (MS). There are currently few established treatments for MS, and interferon-beta (IFN-beta) therapy is one of the most promising - proposed to act as an immunomodulator of the cytokine network reducing inflammatory damage. However, there is increasing evidence that direct effects on the BBB could also be relevant. This review surveys the evidence that IFN-beta stabilizes the BBB, and that this process itself might be the key target. Understanding IFN-beta-derived changes at the BBB will not only provide new insights in the pathogenesis of MS but will also be helpful to develop new, more-specific drugs for MS treatment.

Entities: Disease Gene

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Year: 2006 PMID： 16846804 DOI： 10.1016/j.drudis.2006.06.008

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

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Cited

17 in total

1. Effect of interferon-β on neuroinflammation, brain injury and neurological outcome after experimental subarachnoid hemorrhage.

Authors: Ivo A C W Tiebosch; Rick M Dijkhuizen; Pieter M Cobelens; Mark J R J Bouts; René Zwartbol; Peter H van der Meide; Walter M van den Bergh
Journal: Neurocrit Care Date: 2013-02 Impact factor: 3.210

2. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models.

Authors: Marzena J Fabis; Gwen S Scott; Rhonda B Kean; Hilary Koprowski; D Craig Hooper
Journal: Proc Natl Acad Sci U S A Date: 2007-03-19 Impact factor: 11.205

3. Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective.

Authors: Hideaki Nishihara; Britta Engelhardt
Journal: Handb Exp Pharmacol Date: 2022

4. FTY720 Exacerbates Blood-Brain Barrier Dysfunction Induced by IgG Derived from Patients with NMO and MOG Disease.

Authors: Shunsuke Yoshimura; Shinsuke Nakagawa; Toshiyuki Takahashi; Keiko Tanaka; Akira Tsujino
Journal: Neurotox Res Date: 2021-05-17 Impact factor: 3.911

5. Lymphocyte subsets show different response patterns to in vivo bound natalizumab--a flow cytometric study on patients with multiple sclerosis.

Authors: Andrea Harrer; Georg Pilz; Max Einhaeupl; Katrin Oppermann; Wolfgang Hitzl; Peter Wipfler; Johann Sellner; Stefan Golaszewski; Shahrzad Afazel; Elisabeth Haschke-Becher; Eugen Trinka; Joerg Kraus
Journal: PLoS One Date: 2012-02-20 Impact factor: 3.240

The impact of interferon-beta treatment on the blood-brain barrier.

1. Effect of interferon-β on neuroinflammation, brain injury and neurological outcome after experimental subarachnoid hemorrhage.

2. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models.

3. Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective.

4. FTY720 Exacerbates Blood-Brain Barrier Dysfunction Induced by IgG Derived from Patients with NMO and MOG Disease.

5. Lymphocyte subsets show different response patterns to in vivo bound natalizumab--a flow cytometric study on patients with multiple sclerosis.

6. Interferon-β suppresses murine Th1 cell function in the absence of antigen-presenting cells.

7. Tight junction proteins expression and modulation in immune cells and multiple sclerosis.

8. Bridging the species divide: transgenic mice humanized for type-I interferon response.

9. Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes.

Review 10. Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.