Literature DB >> 16845408

Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?

Nancy E Thomas1, Marianne Berwick, Marila Cordeiro-Stone.   

Abstract

Although BRAF V600 mutations in melanocytic tumors are not UV-signature mutations, it is plausible that they could still arise from error-prone replication of UV-damaged DNA. We propose a mechanism for their origin, taking into consideration melanocytic-specific BRAF tandem mutations, nearby potential pyrimidine dimer sites, the properties of specialized DNA polymerases, and biological selection.

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Year:  2006        PMID： 16845408     DOI： 10.1038/sj.jid.5700458

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  21 in total

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Review 2.  UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.

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3.  Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma.

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4.  Mechanisms of chromosomal instability in melanoma.

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Review 9.  From melanocytes to melanomas.

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Journal:  Nat Rev Cancer       Date:  2016-04-29       Impact factor: 60.716

10.  Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma.

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