| Literature DB >> 16844115 |
Cristina Méndez Vidal1, Magdalena Prahl, Klas G Wiman.
Abstract
Wig-1 is a p53-induced zinc finger protein. Here we show that human Wig-1 binds long (>or=23 bp) dsRNAs with 5'-overhangs. The first zinc finger domain is necessary but not sufficient for this dsRNA-binding in vitro. Wig-1 also binds dsRNA in living cells via zinc fingers 1 and 2. Both zinc fingers 1 and 2 are important for Wig-1-mediated growth suppression. Moreover, Wig-1 binds 21 bp dsRNAs with 3'-protruding ends. These findings demonstrate that human Wig-1 can bind different types of dsRNAs, including dsRNAs resembling small interfering RNAs (siRNAs) and microRNAs (miRNAs), and indicate that dsRNA binding has a role in Wig-1-mediated regulation of cell growth.Entities:
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Year: 2006 PMID： 16844115 DOI： 10.1016/j.febslet.2006.07.005
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124