Literature DB >> 16840354

Induction of the early growth response 1 gene by Epstein-Barr virus lytic transactivator Zta.

Yao Chang1, Heng-Huan Lee, Yu-Te Chen, Jean Lu, Shih-Yi Wu, Chaio-Wei Chen, Kenzo Takada, Ching-Hwa Tsai.   

Abstract

Early growth response 1 (Egr-1) is a cellular transcription factor involved in diverse biologic functions. Egr-1 has been associated with Epstein-Barr virus (EBV) infection, but it is still unknown whether any EBV protein regulates Egr-1 expression. In this study, we first showed that EBV reactivation is involved in upregulation of Egr-1 and that Egr-1 can be induced by Zta, an EBV lytic transactivator. Zta not only binds to the Egr-1 promoter but also activates the ERK signaling pathway to trigger binding of Elk-1 to the Egr-1 promoter. In addition, knockdown of Egr-1 significantly reduces the spontaneous expression of Zta and Rta in EBV-infected 293 cells, suggesting that a positive-feedback network involving Egr-1 is required for EBV reactivation. This study also implies that Zta has the potential to affect expression of certain genes through Egr-1.

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Year:  2006        PMID： 16840354      PMCID： PMC1563714          DOI： 10.1128/JVI.02608-05

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  55 in total

1.  Requirement for cell-to-cell contact in Epstein-Barr virus infection of nasopharyngeal carcinoma cells and keratinocytes.

Authors:  Y Chang; C H Tung; Y T Huang; J Lu; J Y Chen; C H Tsai
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  Induction of Epstein-Barr virus latent membrane protein 1 by a lytic transactivator Rta.

Authors:  Yao Chang; Heng-Huan Lee; Shih-Shin Chang; Tsuey-Ying Hsu; Pei-Wen Wang; Yu-Sun Chang; Kenzo Takada; Ching-Hwa Tsai
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

3.  NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death.

Authors:  Raphaël Thyss; Virginie Virolle; Véronique Imbert; Jean-François Peyron; Daniel Aberdam; Thierry Virolle
Journal:  EMBO J       Date:  2004-12-16       Impact factor: 11.598

4.  Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.

Authors:  C Liu; E Adamson; D Mercola
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

5.  Early growth response-1-dependent apoptosis is mediated by p53.

Authors:  P Nair; S Muthukkumar; S F Sells; S S Han; V P Sukhatme; V M Rangnekar
Journal:  J Biol Chem       Date:  1997-08-08       Impact factor: 5.157

6.  Egr-1 activates basic fibroblast growth factor transcription. Mechanistic implications for astrocyte proliferation.

Authors:  E Biesiada; M Razandi; E R Levin
Journal:  J Biol Chem       Date:  1996-08-02       Impact factor: 5.157

7.  Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2.

Authors:  F S Santiago; H C Lowe; F L Day; C N Chesterman; L M Khachigian
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

8.  Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.

Authors:  J L Schwachtgen; P Houston; C Campbell; V Sukhatme; M Braddock
Journal:  J Clin Invest       Date:  1998-06-01       Impact factor: 14.808

9.  Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.

Authors:  C Hodge; J Liao; M Stofega; K Guan; C Carter-Su; J Schwartz
Journal:  J Biol Chem       Date:  1998-11-20       Impact factor: 5.157

10.  Stress-induced immediate-early gene, egr-1, involves activation of p38/JNK1.

Authors:  C P Lim; N Jain; X Cao
Journal:  Oncogene       Date:  1998-06-04       Impact factor: 9.867
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  39 in total

1.  Cell membrane-bound Kaposi's sarcoma-associated herpesvirus-encoded glycoprotein B promotes virus latency by regulating expression of cellular Egr-1.

Authors:  Ossie F Dyson; Christopher M Traylen; Shaw M Akula
Journal:  J Biol Chem       Date:  2010-09-23       Impact factor: 5.157

2.  Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice.

Authors:  Hui-Wen Yao; Shih-Heng Chen; Ching Li; Yuk-Ying Tung; Shun-Hua Chen
Journal:  J Virol       Date:  2012-05-30       Impact factor: 5.103

Review 3.  Regulation of the latent-lytic switch in Epstein-Barr virus.

Authors:  Shannon C Kenney; Janet E Mertz
Journal:  Semin Cancer Biol       Date:  2014-01-20       Impact factor: 15.707

4.  Dysregulation of Dual-Specificity Phosphatases by Epstein-Barr Virus LMP1 and Its Impact on Lymphoblastoid Cell Line Survival.

Authors:  Kai-Min Lin; Sue-Jane Lin; Juin-Han Lin; Pei-Yi Lin; Pu-Lin Teng; Hsueh-Erh Wu; Te-Huei Yeh; Ying-Piao Wang; Mei-Ru Chen; Ching-Hwa Tsai
Journal:  J Virol       Date:  2020-01-31       Impact factor: 5.103

5.  Cellular immediate-early gene expression occurs kinetically upstream of Epstein-Barr virus bzlf1 and brlf1 following cross-linking of the B cell antigen receptor in the Akata Burkitt lymphoma cell line.

Authors:  Jianjiang Ye; Lyndle Gradoville; George Miller
Journal:  J Virol       Date:  2010-09-22       Impact factor: 5.103

6.  Evaluation of a prediction protocol to identify potential targets of epigenetic reprogramming by the cancer associated Epstein Barr virus.

Authors:  Kirsty Flower; Elizabeth Hellen; Melanie J Newport; Susan Jones; Alison J Sinclair
Journal:  PLoS One       Date:  2010-02-26       Impact factor: 3.240

7.  Early growth response-1 protein is induced by JC virus infection and binds and regulates the JC virus promoter.

Authors:  Luca Romagnoli; Ilker K Sariyer; Jacqueline Tung; Mariha Feliciano; Bassel E Sawaya; Luis Del Valle; Pasquale Ferrante; Kamel Khalili; Mahmut Safak; Martyn K White
Journal:  Virology       Date:  2008-03-18       Impact factor: 3.616

8.  Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice.

Authors:  Shih-Heng Chen; Hui-Wen Yao; I-Te Chen; Biehuoy Shieh; Ching Li; Shun-Hua Chen
Journal:  J Clin Invest       Date:  2008-10       Impact factor: 14.808

9.  Epstein-Barr virus lytic transactivator Zta enhances chemotactic activity through induction of interleukin-8 in nasopharyngeal carcinoma cells.

Authors:  Meichi Hsu; Shih-Yi Wu; Shih-Shin Chang; Ih-Jen Su; Ching-Hwa Tsai; Siao-Jing Lai; Ai-Li Shiau; Kenzo Takada; Yao Chang
Journal:  J Virol       Date:  2008-01-30       Impact factor: 5.103

10.  The Epstein-Barr virus lytic cycle activator Zta interacts with methylated ZRE in the promoter of host target gene egr1.

Authors:  James Heather; Kirsty Flower; Samine Isaac; Alison J Sinclair
Journal:  J Gen Virol       Date:  2009-03-04       Impact factor: 3.891
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