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Literature DB >> 168399

Effect of 2-deoxy-D-glucose on herpesvirus-induced inhibition of cellular DNA synthesis.

Abstract

In pseudorabies virus-infected cells host DNA synthesis is turned off 4 to 5 h postinfection. In the presence of 0.5 mM 2-deoxy-D-glucose, however, synthesis of both cellular and viral DNA proceeds unimpaired throughout the virus replication cycle. The uptake of radioactive thymidine into mock-infected cells is not altered in the presence of 2-deoxy-D-glucose. Virus-specific protein synthesis and particle formation also proceed in medium containing the deoxy sugar, but the virus particles produced are noninfectious and cell fusion is inhibited.

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Year: 1975 PMID： 168399 PMCID： PMC354657

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

14 in total

1. THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. II. THE RELATION BETWEEN PROTEIN SYNTHESIS AND THE DUPLICATION OF VIRAL DNA IN INFECTED HEP-2 CELLS.

Authors: B ROIZMAN; P R ROANE
Journal: Virology Date: 1964-02 Impact factor: 3.616

Effect of 2-deoxy-D-glucose on herpesvirus-induced inhibition of cellular DNA synthesis.

1. THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. II. THE RELATION BETWEEN PROTEIN SYNTHESIS AND THE DUPLICATION OF VIRAL DNA IN INFECTED HEP-2 CELLS.

2. MECHANISM OF INHIBITION OF CELLULAR DNA SYNTHESIS BY PSEUDORABIES VIRUS.

3. Two different mechanisms of the inhibition of the multiplication of enveloped viruses by glucosamine.

4. Inhibition of the multiplication of enveloped RNA-viruses by glucosamine and 2-deoxy-D-glucose.

5. Nucleoside-diphosphate derivatives of 2-deoxy-D-glucose in animal cells.

6. Effect of 2-deoxy-D-glucose on the multiplication of Semliki Forest virus and the reversal of the block by mannose.

7. Inhibition of glycoprotein biosynthesis of influenza virus by D-glucosamine and 2-deoxy-D-glucose.

8. Kinetics of cellular and viral DNA synthesis in equine abortion (herpes) virus infection of L-M cells.

9. Inhibition of herpes virus-induced cell fusion by concanavalin A, antisera, and 2-deoxy-D-glucose.

10. Inhibition of glycosylation of the influenza virus hemagglutinin.

1. Cell cycle-dependent multiplication of avian adenoviruses in chicken embryo fibroblasts.

Review 2. Viral activation of cellular metabolism.

3. Immunoprecipitation of herpes simplex virus type 1 antigens with different antisera and human cerebrospinal fluids.

4. The "glucose effect" in acute hepatic porphyrias and in experimental porphyria.

5. Inhibition by monensin of human cytomegalovirus DNA replication.