Literature DB >> 16836417

Synthesis and biological evaluation of manzamine analogues.

Jeffrey D Winkler1, Allyn T Londregan, Justin R Ragains, Mark T Hamann.   

Abstract

[Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.

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Year:  2006        PMID： 16836417      PMCID： PMC4918913          DOI： 10.1021/ol061320b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

1.  Drugs. Reinventing an ancient cure for malaria.

Authors:  E Marshall
Journal:  Science       Date:  2000-10-20       Impact factor: 47.728

2.  Marine natural products as prototype agrochemical agents.

Authors:  Jiangnan Peng; Xiaoyu Shen; Khalid A El Sayed; D Charles Dunbar; Tony L Perry; Scott P Wilkins; Mark T Hamann; Steve Bobzin; Joseph Huesing; Robin Camp; Mike Prinsen; Dan Krupa; Margaret A Wideman
Journal:  J Agric Food Chem       Date:  2003-04-09       Impact factor: 5.279

3.  New manzamine alkaloids with potent activity against infectious diseases.

Authors:  K A El Sayed; M Kelly; U A Kara; K K Ang; I Katsuyama; D C Dunbar; A A Khan; M T Hamann
Journal:  J Am Chem Soc       Date:  2001-03-07       Impact factor: 15.419

4.  Malaria. A renewed assault on an old and deadly foe.

Authors:  E Marshall
Journal:  Science       Date:  2000-10-20       Impact factor: 47.728

5.  In vivo antimalarial activity of the beta-carboline alkaloid manzamine A.

Authors:  K K Ang; M J Holmes; T Higa; M T Hamann; U A Kara
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

Review 6.  Malaria: new developments in treatment and prevention.

Authors:  P Newton; N White
Journal:  Annu Rev Med       Date:  1999       Impact factor: 13.739

7.  Recent developments in the chemotherapy of malaria.

Authors:  A Bell
Journal:  IDrugs       Date:  2000-03

8.  The First Total Syntheses of Ircinol A, Ircinal A, and Manzamines A and D.

Authors:  Jeffrey D Winkler; Jeffrey M Axten
Journal:  J Am Chem Soc       Date:  1998       Impact factor: 15.419

9.  Palladium-catalyzed cross-coupling reaction of bis(pinacolato)diboron with 1-alkenyl halides or triflates: convenient synthesis of unsymmetrical 1,3-dienes via the borylation-coupling sequence.

Authors:  Jun Takagi; Kou Takahashi; Tatsuo Ishiyama; Norio Miyaura
Journal:  J Am Chem Soc       Date:  2002-07-10       Impact factor: 15.419
  9 in total
  5 in total

1.  An expeditious route to eight-membered heterocycles by nickel-catalyzed cycloaddition: low-temperature C(sp)2-C(sp)3 bond cleavage.

Authors:  Puneet Kumar; Kainan Zhang; Janis Louie
Journal:  Angew Chem Int Ed Engl       Date:  2012-07-17       Impact factor: 15.336

2.  Reductive N-alkylation of nitroarenes: a green approach for the N-alkylation of natural products.

Authors:  Amir E Wahba; Mark T Hamann
Journal:  J Org Chem       Date:  2012-04-30       Impact factor: 4.354

3.  Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections.

Authors:  Jiangnan Peng; Sucheta Kudrimoti; Sivaprakasam Prasanna; Srinivas Odde; Robert J Doerksen; Hari K Pennaka; Yeun-Mun Choo; Karumanchi V Rao; Babu L Tekwani; Vamsi Madgula; Shabana I Khan; Bin Wang; Alejandro M S Mayer; Melissa R Jacob; Lan Chun Tu; Jürg Gertsch; Mark T Hamann
Journal:  J Med Chem       Date:  2010-01-14       Impact factor: 7.446

4.  Synthetic modification of manzamine A via Grubbs metathesis. Novel structures with enhanced antibacterial and antiprotozoal properties.

Authors:  Jeffrey D Winkler; Allyn T Londregan; Mark T Hamann
Journal:  Org Lett       Date:  2007-10-05       Impact factor: 6.005

Review 5.  Application of the Asymmetric Pictet-Spengler Reaction in the Total Synthesis of Natural Products and Relevant Biologically Active Compounds.

Authors:  Majid M Heravi; Vahideh Zadsirjan; Masumeh Malmir
Journal:  Molecules       Date:  2018-04-18       Impact factor: 4.411
  5 in total

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