OBJECTIVE: To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity. METHODS: The authors measured zinc, copper, iron, manganese, and aluminum and Abeta levels in postmortem neocortical tissue from patients with AD (n = 10), normal age-matched control subjects (n = 14), patients with schizophrenia (n = 26), and patients with schizophrenia with amyloid (n = 8). Severity of cognitive impairment was assessed with the Clinical Dementia Rating Scale (CDR). RESULTS: There was a significant, more than twofold, increase of tissue zinc in the AD-affected cortex compared with the other groups. Zinc levels increased with tissue amyloid levels. Zinc levels were significantly elevated in the most severely demented cases (CDR 4 to 5) and in cases that had an amyloid burden greater than 8 plaques/mm(2). Levels of other metals did not differ between groups. CONCLUSIONS: Brain zinc accumulation is a prominent feature of advanced Alzheimer disease (AD) and is biochemically linked to brain amyloid beta-peptide accumulation and dementia severity in AD.
OBJECTIVE: To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity. METHODS: The authors measured zinc, copper, iron, manganese, and aluminum and Abeta levels in postmortem neocortical tissue from patients with AD (n = 10), normal age-matched control subjects (n = 14), patients with schizophrenia (n = 26), and patients with schizophrenia with amyloid (n = 8). Severity of cognitive impairment was assessed with the Clinical Dementia Rating Scale (CDR). RESULTS: There was a significant, more than twofold, increase of tissue zinc in the AD-affected cortex compared with the other groups. Zinc levels increased with tissue amyloid levels. Zinc levels were significantly elevated in the most severely demented cases (CDR 4 to 5) and in cases that had an amyloid burden greater than 8 plaques/mm(2). Levels of other metals did not differ between groups. CONCLUSIONS: Brain zinc accumulation is a prominent feature of advanced Alzheimer disease (AD) and is biochemically linked to brain amyloid beta-peptide accumulation and dementia severity in AD.
Authors: Stefano L Sensi; Pierre Paoletti; Jae-Young Koh; Elias Aizenman; Ashley I Bush; Michal Hershfinkel Journal: J Neurosci Date: 2011-11-09 Impact factor: 6.167
Authors: Matthew Schrag; Andrew Crofton; Matthew Zabel; Arshad Jiffry; David Kirsch; April Dickson; Xiao Wen Mao; Harry V Vinters; Dylan W Domaille; Christopher J Chang; Wolff Kirsch Journal: J Alzheimers Dis Date: 2011 Impact factor: 4.472
Authors: Shino Magaki; Ravi Raghavan; Claudius Mueller; Kerby C Oberg; Harry V Vinters; Wolff M Kirsch Journal: Neurosci Lett Date: 2007-03-03 Impact factor: 3.046
Authors: Dorothea Strozyk; Lenore J Launer; Paul A Adlard; Robert A Cherny; Andrew Tsatsanis; Irene Volitakis; Kaj Blennow; Helen Petrovitch; Lon R White; Ashley I Bush Journal: Neurobiol Aging Date: 2007-12-18 Impact factor: 4.673