Literature DB >> 16831471

CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates.

Nazira El-Hage1, Guanghan Wu, Jayakrishna Ambati, Annadora J Bruce-Keller, Pamela E Knapp, Kurt F Hauser.   

Abstract

To assess the role of CCL2/MCP-1 in opiate drug abuse and HIV-1 comorbidity, the effects of systemic morphine and intrastriatal HIV-1 Tat on macrophage/microglial and astroglial activation were assessed in wild type and CCR2 null mice. Tat and/or morphine additively increased the proportion of CCL2 immunoreactive astroglia. The effects of morphine were prevented by naltrexone. Glial activation was significantly reduced in CCR2-/- versus wild-type mice following Tat or morphine plus Tat exposure. Thus, CCR2 contributes to local glial activation caused by Tat alone or in the presence of opiates, implicating CCR2 signaling in HIV-1 neuropathogenesis in drug abusers and non-abusers.

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Year:  2006        PMID： 16831471      PMCID： PMC4310703          DOI： 10.1016/j.jneuroim.2006.05.027

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


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