| Literature DB >> 16830892 |
Takeshi Isoda1, Hideki Ushirogochi, Koichi Satoh, Tsuyoshi Takasaki, Itsuki Yamamura, Chisato Sato, Ado Mihira, Takao Abe, Satoshi Tamai, Shigeki Yamamoto, Toshio Kumagai, Yoshimitsu Nagao.
Abstract
We discovered an orally active carbapenem, L-084, through pharmacokinetic studies on various prodrug esters of (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-l-methyl-2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-1-carbapen-2-em-3-carboxylic acid (LJC11,036). L-084 showed a strong antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibited the highest intestinal absorption among synthesized prodrugs of LJC11,036.Entities:
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Year: 2006 PMID： 16830892 DOI： 10.1038/ja.2006.34
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649