Literature DB >> 16829620

Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury.

Diana G Scorpio1, Friederike D von Loewenich, Heike Göbel, Christian Bogdan, J Stephen Dumler.   

Abstract

In mice, Anaplasma phagocytophilum control is independent of phagocyte oxidase (phox), inducible NO synthase (NOS2), tumor necrosis factor (TNF), and MyD88 Toll-like receptor signaling. We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself.

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Year:  2006        PMID： 16829620      PMCID： PMC1489578          DOI： 10.1128/CVI.00092-06

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  31 in total

Review 1.  Toll-like receptors and their ligands.

Authors:  G M Barton; R Medzhitov
Journal:  Curr Top Microbiol Immunol       Date:  2002       Impact factor: 4.291

2.  Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation.

Authors:  Jason A Carlyon; Wai-Tsing Chan; Jorge Galán; Dirk Roos; Erol Fikrig
Journal:  J Immunol       Date:  2002-12-15       Impact factor: 5.422

Review 3.  Nitric oxide and the immune response.

Authors:  C Bogdan
Journal:  Nat Immunol       Date:  2001-10       Impact factor: 25.606

4.  Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis.

Authors:  M Akkoyunlu; S E Malawista; J Anguita; E Fikrig
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

5.  Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation.

Authors:  Brahm H Segal; Douglas B Kuhns; Li Ding; John I Gallin; Steven M Holland
Journal:  J Leukoc Biol       Date:  2002-03       Impact factor: 4.962

6.  Gamma interferon dominates the murine cytokine response to the agent of human granulocytic ehrlichiosis and helps to control the degree of early rickettsemia.

Authors:  M Akkoyunlu; E Fikrig
Journal:  Infect Immun       Date:  2000-04       Impact factor: 3.441

7.  Pathology, immunohistology, and cytokine responses in early phases of human granulocytic ehrlichiosis in a murine model.

Authors:  M E Martin; J E Bunnell; J S Dumler
Journal:  J Infect Dis       Date:  2000-01       Impact factor: 5.226

Review 8.  Invasion and survival strategies of Anaplasma phagocytophilum.

Authors:  Jason A Carlyon; Erol Fikrig
Journal:  Cell Microbiol       Date:  2003-11       Impact factor: 3.715

9.  8-nitroguanosine formation in viral pneumonia and its implication for pathogenesis.

Authors:  Takaaki Akaike; Shinichiro Okamoto; Tomohiro Sawa; Jun Yoshitake; Fumio Tamura; Koji Ichimori; Kiminori Miyazaki; Kazumi Sasamoto; Hiroshi Maeda
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-08       Impact factor: 11.205

Review 10.  Toll-like receptors.

Authors:  Kiyoshi Takeda; Tsuneyasu Kaisho; Shizuo Akira
Journal:  Annu Rev Immunol       Date:  2001-12-19       Impact factor: 28.527
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  18 in total

1.  Dexamethasone-induced cytokine changes associated with diminished disease severity in horses infected with Anaplasma phagocytophilum.

Authors:  R S Davies; J E Madigan; E Hodzic; D L Borjesson; J S Dumler
Journal:  Clin Vaccine Immunol       Date:  2011-08-31

2.  MyD88 Mediates Instructive Signaling in Dendritic Cells and Protective Inflammatory Response during Rickettsial Infection.

Authors:  Jeremy Bechelli; Claire Smalley; Xuemei Zhao; Barbara Judy; Patricia Valdes; David H Walker; Rong Fang
Journal:  Infect Immun       Date:  2016-03-24       Impact factor: 3.441

Review 3.  The role of CD8 T lymphocytes in rickettsial infections.

Authors:  David H Walker; J Stephen Dumler
Journal:  Semin Immunopathol       Date:  2015-04-01       Impact factor: 9.623

Review 4.  Anaplasma phagocytophilum: deceptively simple or simply deceptive?

Authors:  Maiara S Severo; Kimberly D Stephens; Michail Kotsyfakis; Joao Hf Pedra
Journal:  Future Microbiol       Date:  2012-06       Impact factor: 3.165

5.  Anaplasma phagocytophilum, interferon gamma production and Stat1 signaling.

Authors:  Kyoung-Seong Choi; J Stephen Dumler
Journal:  Microbiol Immunol       Date:  2013-03       Impact factor: 1.955

6.  Differential innate immune cell activation and proinflammatory response in Anaplasma phagocytophilum infection.

Authors:  Kyoung-Seong Choi; Tonya Webb; Mathias Oelke; Diana G Scorpio; J Stephen Dumler
Journal:  Infect Immun       Date:  2007-04-02       Impact factor: 3.441

Review 7.  Adaptive immunity to Anaplasma pathogens and immune dysregulation: implications for bacterial persistence.

Authors:  Wendy C Brown
Journal:  Comp Immunol Microbiol Infect Dis       Date:  2012-01-04       Impact factor: 2.268

Review 8.  The biological basis of severe outcomes in Anaplasma phagocytophilum infection.

Authors:  J Stephen Dumler
Journal:  FEMS Immunol Med Microbiol       Date:  2011-12-19

9.  Mitogenic component in polar lipid-enriched Anaplasma phagocytophilum membranes.

Authors:  Kyoung-Seong Choi; J Stephen Dumler
Journal:  Clin Vaccine Immunol       Date:  2007-08-08

10.  Stat1 negatively regulates immune-mediated injury with Anaplasma phagocytophilum infection.

Authors:  Kyoung-Seong Choi; Diana G Scorpio; J Stephen Dumler
Journal:  J Immunol       Date:  2014-10-10       Impact factor: 5.422
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