Literature DB >> 22702526

Anaplasma phagocytophilum: deceptively simple or simply deceptive?

Maiara S Severo1, Kimberly D Stephens, Michail Kotsyfakis, Joao Hf Pedra.   

Abstract

Anaplasma phagocytophilum is an obligate intracellular rickettsial pathogen transmitted by ixodid ticks. This bacterium colonizes myeloid and nonmyeloid cells and causes human granulocytic anaplasmosis--an important immunopathological vector-borne disease in the USA, Europe and Asia. Recent studies uncovered novel insights into the mechanisms of A. phagocytophilum pathogenesis and immunity. Here, we provide an overview of the underlying events by which the immune system responds to A. phagocytophilum infection, how this pathogen counteracts host immunity and the contribution of the tick vector for microbial transmission. We also discuss current scientific gaps in the knowledge of A. phagocytophilum biology for the purpose of exchanging research perspectives.

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Year:  2012        PMID： 22702526      PMCID： PMC3397239          DOI： 10.2217/fmb.12.45

Source DB:  PubMed          Journal:  Future Microbiol        ISSN： 1746-0913            Impact factor:   3.165


  81 in total

1.  Infection with Anaplasma phagocytophilum induces multilineage alterations in hematopoietic progenitor cells and peripheral blood cells.

Authors:  J L Johns; K C Macnamara; N J Walker; G M Winslow; D L Borjesson
Journal:  Infect Immun       Date:  2009-06-29       Impact factor: 3.441

2.  Anaplasma phagocytophilum APH_1387 is expressed throughout bacterial intracellular development and localizes to the pathogen-occupied vacuolar membrane.

Authors:  Bernice Huang; Matthew J Troese; Shaojing Ye; Jonathan T Sims; Nathan L Galloway; Dori L Borjesson; Jason A Carlyon
Journal:  Infect Immun       Date:  2010-03-08       Impact factor: 3.441

3.  Neutrophils exposed to A. phagocytophilum under shear stress fail to fully activate, polarize, and transmigrate across inflamed endothelium.

Authors:  U Y Schaff; K A Trott; S Chase; K Tam; J L Johns; J A Carlyon; D C Genetos; N J Walker; S I Simon; D L Borjesson
Journal:  Am J Physiol Cell Physiol       Date:  2010-04-14       Impact factor: 4.249

Review 4.  Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells.

Authors:  Yasuko Rikihisa
Journal:  Nat Rev Microbiol       Date:  2010-04-07       Impact factor: 60.633

5.  Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction.

Authors:  Hua Niu; Vera Kozjak-Pavlovic; Thomas Rudel; Yasuko Rikihisa
Journal:  PLoS Pathog       Date:  2010-02-19       Impact factor: 6.823

6.  Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks.

Authors:  Hameeda Sultana; Girish Neelakanta; Fred S Kantor; Stephen E Malawista; Durland Fish; Ruth R Montgomery; Erol Fikrig
Journal:  J Exp Med       Date:  2010-07-26       Impact factor: 14.307

7.  Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane.

Authors:  Bernice Huang; Matthew J Troese; Dale Howe; Shaojing Ye; Jonathan T Sims; Robert A Heinzen; Dori L Borjesson; Jason A Carlyon
Journal:  Microb Pathog       Date:  2010-06-30       Impact factor: 3.848

8.  Diversity of Anaplasma phagocytophilum strains, USA.

Authors:  Eric Morissette; Robert F Massung; Janet E Foley; A Rick Alleman; Patrick Foley; Anthony F Barbet
Journal:  Emerg Infect Dis       Date:  2009-06       Impact factor: 6.883

9.  Delineating Anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles.

Authors:  Kevin J Bown; Xavier Lambin; Nicholas H Ogden; Michael Begon; Gill Telford; Zerai Woldehiwet; Richard J Birtles
Journal:  Emerg Infect Dis       Date:  2009-12       Impact factor: 6.883

10.  Epigenetic silencing of host cell defense genes enhances intracellular survival of the rickettsial pathogen Anaplasma phagocytophilum.

Authors:  Jose C Garcia-Garcia; Nicole C Barat; Sarah J Trembley; J Stephen Dumler
Journal:  PLoS Pathog       Date:  2009-06-19       Impact factor: 6.823
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  16 in total

1.  The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection.

Authors:  Gang Chen; Xiaowei Wang; Maiara S Severo; Olivia S Sakhon; Mohammad Sohail; Lindsey J Brown; Mayukh Sircar; Greg A Snyder; Eric J Sundberg; Tyler K Ulland; Alicia K Olivier; John F Andersen; Yi Zhou; Guo-Ping Shi; Fayyaz S Sutterwala; Michail Kotsyfakis; Joao H F Pedra
Journal:  Infect Immun       Date:  2014-03-31       Impact factor: 3.441

2.  The E3 ubiquitin ligase XIAP restricts Anaplasma phagocytophilum colonization of Ixodes scapularis ticks.

Authors:  Maiara S Severo; Anthony Choy; Kimberly D Stephens; Olivia S Sakhon; Gang Chen; Duk-Won D Chung; Karine G Le Roch; Gregor Blaha; Joao H F Pedra
Journal:  J Infect Dis       Date:  2013-07-29       Impact factor: 5.226

3.  Anaplasma phagocytophilum inhibits apoptosis and promotes cytoskeleton rearrangement for infection of tick cells.

Authors:  Nieves Ayllón; Margarita Villar; Ann T Busby; Katherine M Kocan; Edmour F Blouin; Elena Bonzón-Kulichenko; Ruth C Galindo; Atilio J Mangold; Pilar Alberdi; José M Pérez de la Lastra; Jesús Vázquez; José de la Fuente
Journal:  Infect Immun       Date:  2013-04-29       Impact factor: 3.441

4.  Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells.

Authors:  Gang Chen; Maiara S Severo; Mohammad Sohail; Olivia S Sakhon; Stephen K Wikel; Michail Kotsyfakis; Joao H F Pedra
Journal:  Parasit Vectors       Date:  2012-10-10       Impact factor: 3.876

5.  Gene expression profile suggests that pigs (Sus scrofa) are susceptible to Anaplasma phagocytophilum but control infection.

Authors:  Ruth C Galindo; Nieves Ayllón; Katja Strašek Smrdel; Mariana Boadella; Beatriz Beltrán-Beck; María Mazariegos; Nerea García; José M Pérez de la Lastra; Tatjana Avsic-Zupanc; Katherine M Kocan; Christian Gortazar; José de la Fuente
Journal:  Parasit Vectors       Date:  2012-08-30       Impact factor: 3.876

6.  Comparative analysis of the infectivity rate of both Borrelia burgdorferi and Anaplasma phagocytophilum in humans and dogs in a New Jersey community.

Authors:  Andrea Gaito; Vedrana Gjivoje; Sebastian Lutz; Ben Baxter
Journal:  Infect Drug Resist       Date:  2014-08-07       Impact factor: 4.003

7.  The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.

Authors:  Xiaowei Wang; Dana K Shaw; Holly L Hammond; Fayyaz S Sutterwala; Manira Rayamajhi; Kari Ann Shirey; Darren J Perkins; Joseph V Bonventre; Thangam S Velayutham; Sean M Evans; Kyle G Rodino; Lauren VieBrock; Karen M Scanlon; Nicholas H Carbonetti; Jason A Carlyon; Edward A Miao; Jere W McBride; Michail Kotsyfakis; Joao H F Pedra
Journal:  PLoS Pathog       Date:  2016-08-02       Impact factor: 6.823

8.  Identification and Characterization of Anaplasma phagocytophilum Proteins Involved in Infection of the Tick Vector, Ixodes scapularis.

Authors:  Margarita Villar; Nieves Ayllón; Katherine M Kocan; Elena Bonzón-Kulichenko; Pilar Alberdi; Edmour F Blouin; Sabine Weisheit; Lourdes Mateos-Hernández; Alejandro Cabezas-Cruz; Lesley Bell-Sakyi; Marie Vancová; Tomáš Bílý; Damien F Meyer; Jan Sterba; Marinela Contreras; Nataliia Rudenko; Libor Grubhoffer; Jesús Vázquez; José de la Fuente
Journal:  PLoS One       Date:  2015-09-04       Impact factor: 3.240

9.  An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum.

Authors:  Adela S Oliva Chávez; James W Fairman; Roderick F Felsheim; Curtis M Nelson; Michael J Herron; LeeAnn Higgins; Nicole Y Burkhardt; Jonathan D Oliver; Todd W Markowski; Timothy J Kurtti; Thomas E Edwards; Ulrike G Munderloh
Journal:  PLoS Pathog       Date:  2015-11-06       Impact factor: 6.823

10.  The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis.

Authors:  Margarita Villar; Vladimir López; Nieves Ayllón; Alejandro Cabezas-Cruz; Juan A López; Jesús Vázquez; Pilar Alberdi; José de la Fuente
Journal:  Parasit Vectors       Date:  2016-08-25       Impact factor: 3.876
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