Literature DB >> 16828550

Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX.

Kyung-Ae Oh1, Garp Yeol Yang, Daniel Jun, Kamil Kuca, Young-Sik Jung.   

Abstract

New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.

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Year:  2006        PMID： 16828550     DOI： 10.1016/j.bmcl.2006.06.063

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

Authors:  Sandip B Bharate; Lilu Guo; Tony E Reeves; Douglas M Cerasoli; Charles M Thompson
Journal:  Bioorg Med Chem       Date:  2009-11-27       Impact factor: 3.641

2.  Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator.

Authors:  Kamil Kuca; Kamil Musilek; Martin Paar; Daniel Jun; Petr Stodulka; Martina Hrabinova; Jan Marek
Journal:  Molecules       Date:  2007-08-20       Impact factor: 4.411

3.  New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

Authors:  Sandip B Bharate; Lilu Guo; Tony E Reeves; Douglas M Cerasoli; Charles M Thompson
Journal:  Bioorg Med Chem Lett       Date:  2009-07-10       Impact factor: 2.823

4.  Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators.

Authors:  Daniel A S Kitagawa; Rafael B Rodrigues; Thiago N Silva; Wellington V Dos Santos; Vinicius C V da Rocha; Joyce S F D de Almeida; Leandro B Bernardo; Taynara Carvalho-Silva; Cintia N Ferreira; Angelo A T da Silva; Alessandro B C Simas; Eugenie Nepovimova; Kamil Kuča; Tanos C C França; Samir F de A Cavalcante
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

Review 5.  Counteracting poisoning with chemical warfare nerve agents.

Authors:  Nikolina Maček Hrvat; Zrinka Kovarik
Journal:  Arh Hig Rada Toksikol       Date:  2020-12-31       Impact factor: 2.078
  5 in total

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