Literature DB >> 16828464

Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1).

Ranjna Kapoor1, Kelly Sy Lim2, Alice Cheng2, Therese Garrick3, Vimal Kapoor2.   

Abstract

Preliminary investigations, studying gene expression and biochemical activities of enzymes d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1), revealed elevated cerebellar KAT-1 and DAAO activities in post-mortem brain samples from schizophrenic versus normal individuals. In addition, we have identified a transcript of DAAO, which was expressed in significantly higher quantities in the diseased cerebellum but not detected in the parietal cortex where DAAO activity is absent.

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Year:  2006        PMID： 16828464     DOI： 10.1016/j.brainres.2006.05.082

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  31 in total

1.  Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia.

Authors:  Surendra P Singh; Vidhi Singh
Journal:  CNS Drugs       Date:  2011-10-01       Impact factor: 5.749

Review 2.  Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies.

Authors:  Emilia H Moscato; Ankit Jain; Xiaoyu Peng; Ethan G Hughes; Josep Dalmau; Rita J Balice-Gordon
Journal:  Eur J Neurosci       Date:  2010-07-14       Impact factor: 3.386

3.  Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging.

Authors:  Xiaoyun Deng; Yiding Zhang; Zhen Chen; Katsushi Kumata; Richard Van; Jian Rong; Tuo Shao; Akiko Hatori; Wakana Mori; Qingzhen Yu; Kuan Hu; Masayuki Fujinaga; Hsiao-Ying Wey; Yihan Shao; Lee Josephson; Giulia Murtas; Loredano Pollegioni; Ming-Rong Zhang; Steven Liang
Journal:  Bioorg Med Chem Lett       Date:  2020-06-09       Impact factor: 2.823

Review 4.  The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies.

Authors:  Wei Hu; Matthew L MacDonald; Daniel E Elswick; Robert A Sweet
Journal:  Ann N Y Acad Sci       Date:  2014-10-14       Impact factor: 5.691

Review 5.  Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.

Authors:  Joseph T Coyle; Alo Basu; Michael Benneyworth; Darrick Balu; Glenn Konopaske
Journal:  Handb Exp Pharmacol       Date:  2012

6.  D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.

Authors:  Michael Popiolek; John F Ross; Erik Charych; Pranab Chanda; Eckart D Gundelfinger; Stephen J Moss; Nicholas J Brandon; Mark H Pausch
Journal:  J Biol Chem       Date:  2011-06-23       Impact factor: 5.157

7.  D-amino acid oxidase activity and expression are increased in schizophrenia.

Authors:  P W J Burnet; S L Eastwood; G C Bristow; B R Godlewska; P Sikka; M Walker; P J Harrison
Journal:  Mol Psychiatry       Date:  2008-07       Impact factor: 15.992

8.  Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study.

Authors:  Gregor Habl; Mathias Zink; Georg Petroianu; Manfred Bauer; Thomas Schneider-Axmann; Martina von Wilmsdorff; Peter Falkai; Fritz A Henn; Andrea Schmitt
Journal:  J Neural Transm (Vienna)       Date:  2009-10-13       Impact factor: 3.575

Review 9.  Kynurenines, Gender and Neuroinflammation; Showcase Schizophrenia.

Authors:  J de Bie; C K Lim; G J Guillemin
Journal:  Neurotox Res       Date:  2016-06-24       Impact factor: 3.911

Review 10.  The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.

Authors:  L Verrall; P W J Burnet; J F Betts; P J Harrison
Journal:  Mol Psychiatry       Date:  2009-09-29       Impact factor: 15.992
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