Literature DB >> 16827891

Contribution of interferon-beta to the immune activation induced by double-stranded DNA.

Hidekazu Shirota1, Ken J Ishii, Hiroki Takakuwa, Dennis M Klinman.   

Abstract

Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial/viral factors. Current findings indicate that interferon-beta (IFN-beta) plays a key role in the stimulatory cascade triggered by dsDNA. Both immune and non-immune cells respond to intracytoplasmic dsDNA by up-regulating IFN-beta) expression, a process that reduces host susceptibility to infection. The immune activation induced by dsDNA is independent of MyD88, TRIF and DNA-PKcs, indicating that a Toll-like receptor-independent mechanism underlies the cellular activation mediated by intracytoplasmic dsDNA.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16827891      PMCID： PMC1782301          DOI： 10.1111/j.1365-2567.2006.02367.x

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  35 in total

1.  A Toll-like receptor recognizes bacterial DNA.

Authors:  H Hemmi; O Takeuchi; T Kawai; T Kaisho; S Sato; H Sanjo; M Matsumoto; K Hoshino; H Wagner; K Takeda; S Akira
Journal:  Nature       Date:  2000-12-07       Impact factor: 49.962

2.  Natural adjuvants: endogenous activators of dendritic cells.

Authors:  S Gallucci; M Lolkema; P Matzinger
Journal:  Nat Med       Date:  1999-11       Impact factor: 53.440

3.  Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway.

Authors:  S Basu; R J Binder; R Suto; K M Anderson; P K Srivastava
Journal:  Int Immunol       Date:  2000-11       Impact factor: 4.823

4.  Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses.

Authors:  Y Shi; W Zheng; K L Rock
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

5.  Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock.

Authors:  Hidekazu Shirota; Ihsan Gursel; Mayda Gursel; Dennis M Klinman
Journal:  J Immunol       Date:  2005-04-15       Impact factor: 5.422

6.  Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.

Authors:  Hideyuki Yoshida; Yasutaka Okabe; Kohki Kawane; Hidehiro Fukuyama; Shigekazu Nagata
Journal:  Nat Immunol       Date:  2004-11-28       Impact factor: 25.606

7.  Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways.

Authors:  Kei Yasuda; Yoshiyuki Ogawa; Ikuko Yamane; Makiya Nishikawa; Yoshinobu Takakura
Journal:  J Leukoc Biol       Date:  2004-10-20       Impact factor: 4.962

8.  Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways.

Authors:  Kei Yasuda; Philipp Yu; Carsten J Kirschning; Beatrix Schlatter; Frank Schmitz; Antje Heit; Stefan Bauer; Hubertus Hochrein; Hermann Wagner
Journal:  J Immunol       Date:  2005-05-15       Impact factor: 5.422

9.  Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: consequences on inflammation.

Authors:  Patrice Decker; Harpreet Singh-Jasuja; Sabine Haager; Ina Kötter; Hans-Georg Rammensee
Journal:  J Immunol       Date:  2005-03-15       Impact factor: 5.422

10.  Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells.

Authors:  B Sauter; M L Albert; L Francisco; M Larsson; S Somersan; N Bhardwaj
Journal:  J Exp Med       Date:  2000-02-07       Impact factor: 14.307
View more
  8 in total

1.  Cytosolic DNA-activated human dendritic cells are potent activators of the adaptive immune response.

Authors:  Katalin Kis-Toth; Attila Szanto; To-Ha Thai; George C Tsokos
Journal:  J Immunol       Date:  2011-06-27       Impact factor: 5.422

2.  DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.

Authors:  Qiujing Yu; Yuliya V Katlinskaya; Christopher J Carbone; Bin Zhao; Kanstantsin V Katlinski; Hui Zheng; Manti Guha; Ning Li; Qijun Chen; Ting Yang; Christopher J Lengner; Roger A Greenberg; F Brad Johnson; Serge Y Fuchs
Journal:  Cell Rep       Date:  2015-04-23       Impact factor: 9.423

3.  A strategy of tumor treatment in mice with doxorubicin-cyclophosphamide combination based on dendritic cell activation by human double-stranded DNA preparation.

Authors:  Ekaterina A Alyamkina; Valeriy P Nikolin; Nelly A Popova; Evgenia V Dolgova; Anastasia S Proskurina; Konstantin E Orishchenko; Yaroslav R Efremov; Elena R Chernykh; Alexandr A Ostanin; Sergey V Sidorov; Dmitriy M Ponomarenko; Stanislav N Zagrebelniy; Sergey S Bogachev; Mikhail A Shurdov
Journal:  Genet Vaccines Ther       Date:  2010-11-01

4.  Contribution of IRF-3 mediated IFNbeta production to DNA vaccine dependent cellular immune responses.

Authors:  Hidekazu Shirota; Lev Petrenko; Toshio Hattori; Dennis M Klinman
Journal:  Vaccine       Date:  2009-02-10       Impact factor: 3.641

5.  The induction of HMGB1 release from RAW 264.7 cells by transfected DNA.

Authors:  Weiwen Jiang; David S Pisetsky
Journal:  Mol Immunol       Date:  2007-11-26       Impact factor: 4.407

Review 6.  Augmentation of effects of interferon-stimulated genes by reversal of epigenetic silencing: potential application to melanoma.

Authors:  Ernest C Borden
Journal:  Cytokine Growth Factor Rev       Date:  2007-08-06       Impact factor: 7.638

Review 7.  Harnessing DNA-induced immune responses for improving cancer vaccines.

Authors:  Andrés A Herrada; Nicole Rojas-Colonelli; Paula González-Figueroa; Jonathan Roco; César Oyarce; Maarten A Ligtenberg; Alvaro Lladser
Journal:  Hum Vaccin Immunother       Date:  2012-10-30       Impact factor: 3.452

8.  Evaluation of signal transduction pathways after transient cutaneous adenoviral gene delivery.

Authors:  Lars Steinstraesser; Michael Sorkin; Frank Jacobsen; Sammy Al-Benna; Marco Rainer Kesting; Andreas David Niederbichler; Jan-Michel Otte; Tobias Hirsch; Jadwiga Stupka; Hans-Ulrich Steinau; Matthias Schulte
Journal:  BMC Immunol       Date:  2011-01-21       Impact factor: 3.615
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.