Literature DB >> 16823176

Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact.

Marian Grade1, Heinz Becker, Torsten Liersch, Thomas Ried, B Michael Ghadimi.   

Abstract

Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact.

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Year:  2006        PMID： 16823176      PMCID： PMC4615150          DOI： 10.1155/2006/173815

Source DB:  PubMed          Journal:  Cell Oncol        ISSN： 1570-5870            Impact factor:   6.730


  26 in total

Review 1.  Patterns of Chromosomal Aberrations in Solid Tumors.

Authors:  Marian Grade; Michael J Difilippantonio; Jordi Camps
Journal:  Recent Results Cancer Res       Date:  2015

2.  The role of LINE-1 methylation in predicting survival among colorectal cancer patients: a meta-analysis.

Authors:  Ding Ye; Danjie Jiang; Yingjun Li; Mingjuan Jin; Kun Chen
Journal:  Int J Clin Oncol       Date:  2017-03-25       Impact factor: 3.402

Review 3.  The consequences of chromosomal aneuploidy on the transcriptome of cancer cells.

Authors:  Thomas Ried; Yue Hu; Michael J Difilippantonio; B Michael Ghadimi; Marian Grade; Jordi Camps
Journal:  Biochim Biophys Acta       Date:  2012-03-06

4.  A new whole genome amplification method for studying clonal evolution patterns in malignant colorectal polyps.

Authors:  Daniela Hirsch; Jordi Camps; Sudhir Varma; Ralf Kemmerling; Mark Stapleton; Thomas Ried; Timo Gaiser
Journal:  Genes Chromosomes Cancer       Date:  2012-02-15       Impact factor: 5.006

5.  Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas.

Authors:  Marian Grade; Patrick Hörmann; Sandra Becker; Amanda B Hummon; Danny Wangsa; Sudhir Varma; Richard Simon; Torsten Liersch; Heinz Becker; Michael J Difilippantonio; B Michael Ghadimi; Thomas Ried
Journal:  Cancer Res       Date:  2007-01-01       Impact factor: 12.701

6.  Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas.

Authors:  Dionysios J Papachristou; Angeliki Korpetinou; Efstathia Giannopoulou; Anna G Antonacopoulou; Helen Papadaki; Petros Grivas; Chrisoula D Scopa; Haralabos P Kalofonos
Journal:  Virchows Arch       Date:  2011-07-18       Impact factor: 4.064

7.  Effects of the miR-143/-145 microRNA cluster on the colon cancer proteome and transcriptome.

Authors:  Kerry M Bauer; Amanda B Hummon
Journal:  J Proteome Res       Date:  2012-08-27       Impact factor: 4.466

8.  Novel mouse model recapitulates genome and transcriptome alterations in human colorectal carcinomas.

Authors:  Nicole E McNeil; Hesed M Padilla-Nash; Floryne O Buishand; Yue Hue; Thomas Ried
Journal:  Genes Chromosomes Cancer       Date:  2016-11-01       Impact factor: 5.006

9.  Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy.

Authors:  Marian Grade; Jochen Gaedcke; Danny Wangsa; Sudhir Varma; Jaje Beckmann; Torsten Liersch; Clemens Hess; Heinz Becker; Michael J Difilippantonio; Thomas Ried; B Michael Ghadimi
Journal:  Cancer Genet Cytogenet       Date:  2009-08

10.  Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci.

Authors:  Marianne Berg; Trude H Agesen; Espen Thiis-Evensen; Marianne A Merok; Manuel R Teixeira; Morten H Vatn; Arild Nesbakken; Rolf I Skotheim; Ragnhild A Lothe
Journal:  Mol Cancer       Date:  2010-05-06       Impact factor: 27.401
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