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Literature DB >> 16822586

Cocaine and amphetamine regulated transcript (CART) and the stress response.

Ersin O Koylu¹, Burcu Balkan, Michael J Kuhar, Sakire Pogun.

Abstract

CART is expressed abundantly in the hypothalamic paraventricular nucleus and locus coeruleus, major corticotropin releasing factor (CRF) and noradrenaline sources, respectively. There is a bidirectional relation between CART and hypothalamo-pituitary-adrenal axis activity. CART stimulates CRF, adrenocorticotropic hormone and glucocorticoid secretion, whereas CRF and glucocorticoids increase the transcriptional activity of the CART gene; adrenalectomy declines CART expression in the hypothalamus. Stress exposure modulates CART expression in hypothalamus and amygdala in rat brain in a region and sex specific manner. CART may be a mediator peptide in the interaction between stress, drug abuse, and feeding. The review discusses the established role of CART as it relates to the stress response.

Entities: Chemical Disease Gene Species

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Year: 2006 PMID： 16822586 DOI： 10.1016/j.peptides.2006.03.032

Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750

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Cited

24 in total

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Authors: A V Akhmadeev
Journal: Neurosci Behav Physiol Date: 2010-03-26

4. Mitochondrial mechanism of neuroprotection by CART.

Authors: Peizhong Mao; Ardi Ardeshiri; Rachel Jacks; Sufang Yang; Patricia D Hurn; Nabil J Alkayed
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6. Interaction of Cocaine- and Amphetamine-regulated Transcript and Neuropeptide Y on Behavior in the Central Nervous System.

Authors: Aynur Müdüroğlu Kirmizibekmez; Murat Mengi; Ertan Yurdakoş
Journal: Noro Psikiyatr Ars Date: 2016-06-01 Impact factor: 1.339

Cocaine and amphetamine regulated transcript (CART) and the stress response.

1. Risk-assessment and coping strategies segregate with divergent intrinsic aerobic capacity in rats.

2. The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer.

3. Localization of CART-positive neurons in the amygdaloid body and the relationship between their immunoreactivity and the sex steroid level.

4. Mitochondrial mechanism of neuroprotection by CART.

5. Increased intake of energy-dense diet and negative energy balance in a mouse model of chronic psychosocial defeat.

6. Interaction of Cocaine- and Amphetamine-regulated Transcript and Neuropeptide Y on Behavior in the Central Nervous System.

7. Region- and sex-specific changes in CART mRNA in rat hypothalamic nuclei induced by forced swim stress.

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10. Unique responses of midbrain CART neurons in macaques to ovarian steroids.