BACKGROUND: The present study aimed at evaluating the expression intensities of the Mcm-2 protein and Ki-67 antigen in squamocellular carcinomas of the oral cavity and comparing their prognostic value. MATERIALS AND METHODS: Forty-nine patients, operated on and treated with radiotherapy for carcinoma of the oral cavity floor and/or the mobile part of the tongue, were retrospectively analyzed. RESULTS: A significant positive correlation was noted between the expression of Mcm-2 protein and that of the Ki-67 antigen, as well as an absence of such correlations with the remaining examined factors. A significant correlation with worse disease-specific survival period (DSS) in the group of patients demonstrating Mcm-2 protein expression in over 10% of cancer cells was detected (5-year cumulative DSS 50% vs. 76%). CONCLUSION: The results suggested that the expression of Mcm-2 protein may be used as a prognostic factor in patients with squamocellular carcinoma of the oral cavity.
BACKGROUND: The present study aimed at evaluating the expression intensities of the Mcm-2 protein and Ki-67 antigen in squamocellular carcinomas of the oral cavity and comparing their prognostic value. MATERIALS AND METHODS: Forty-nine patients, operated on and treated with radiotherapy for carcinoma of the oral cavity floor and/or the mobile part of the tongue, were retrospectively analyzed. RESULTS: A significant positive correlation was noted between the expression of Mcm-2 protein and that of the Ki-67 antigen, as well as an absence of such correlations with the remaining examined factors. A significant correlation with worse disease-specific survival period (DSS) in the group of patients demonstrating Mcm-2 protein expression in over 10% of cancer cells was detected (5-year cumulative DSS 50% vs. 76%). CONCLUSION: The results suggested that the expression of Mcm-2 protein may be used as a prognostic factor in patients with squamocellular carcinoma of the oral cavity.
Authors: Romy van Baars; Heather Griffin; Zhonglin Wu; Yasmina Jay Soneji; Miekel van de Sandt; Rupali Arora; Jacolien van der Marel; Bram Ter Harmsel; Robert Jach; Krzysztof Okon; Hubert Huras; David Jenkins; Wim Quint; John Doorbar Journal: Am J Surg Pathol Date: 2015-11 Impact factor: 6.394
Authors: Shalaka Joshi; Johnathan Watkins; Patrycja Gazinska; John P Brown; Cheryl E Gillett; Anita Grigoriadis; Sarah E Pinder Journal: BMC Cancer Date: 2015-07-25 Impact factor: 4.430
Authors: Julia Brockhaus; Rogerio B Craveiro; Irma Azraq; Christian Niederau; Sarah K Schröder; Ralf Weiskirchen; Joachim Jankowski; Michael Wolf Journal: Biomolecules Date: 2021-06-23