AIM: In this prospective study we present a novel technique of matrix-based chondrocyte transplantation for the treatment of focal cartilage defects. METHOD: 22 patients with chondral or osteochondral femoral defects were treated with 3D-collagen type-I gel seeded with autologous chondrocytes (CaReS). Overall handling of this novel method is described, and results after 2 years follow-up with regard to the ICRS-score are presented. RESULTS: 14 patients were treated because of a focal chondral lesion, in 8 cases subchondral bone had to be reestablished. The average defect size was 6 cm(2). In all cases cell-seeded matrix samples could be fixed with fibrin glue without any problems. The average surgery time was 69 min, length of the surgical approach was 8.2 cm. No surgery-specific problems had to be observed. A significant improvement in IKDC-score, functional score and overall rating after 3 or 6 months up to 2 years follow-up was detected. After 2 years post-OP 13 Patients were evaluated and matrix-based defect treatment by CaReS was rated good to excellent by 84.6 % of the patients. CONCLUSION: Defect treatment with cell-seeded 3D-collagen gel is easy to handle with a good clinical outcome after 2 years follow-up. Further investigations with higher patient number, longer follow-up time and histological and biomechanical sample analysis are needed in order to establish this method as an improvement of conventional ACT.
AIM: In this prospective study we present a novel technique of matrix-based chondrocyte transplantation for the treatment of focal cartilage defects. METHOD: 22 patients with chondral or osteochondral femoral defects were treated with 3D-collagen type-I gel seeded with autologous chondrocytes (CaReS). Overall handling of this novel method is described, and results after 2 years follow-up with regard to the ICRS-score are presented. RESULTS: 14 patients were treated because of a focal chondral lesion, in 8 cases subchondral bone had to be reestablished. The average defect size was 6 cm(2). In all cases cell-seeded matrix samples could be fixed with fibrin glue without any problems. The average surgery time was 69 min, length of the surgical approach was 8.2 cm. No surgery-specific problems had to be observed. A significant improvement in IKDC-score, functional score and overall rating after 3 or 6 months up to 2 years follow-up was detected. After 2 years post-OP 13 Patients were evaluated and matrix-based defect treatment by CaReS was rated good to excellent by 84.6 % of the patients. CONCLUSION: Defect treatment with cell-seeded 3D-collagen gel is easy to handle with a good clinical outcome after 2 years follow-up. Further investigations with higher patient number, longer follow-up time and histological and biomechanical sample analysis are needed in order to establish this method as an improvement of conventional ACT.
Authors: Turgay Efe; Alexander Füglein; Alan Getgood; Thomas J Heyse; Susanne Fuchs-Winkelmann; Thilo Patzer; Bilal F El-Zayat; Stefan Lakemeier; Markus D Schofer Journal: Int Orthop Date: 2011-12-06 Impact factor: 3.075
Authors: Turgay Efe; Alexander Füglein; Thomas J Heyse; Thomas Stein; Nina Timmesfeld; Susanne Fuchs-Winkelmann; Jan Schmitt; Jürgen R J Paletta; Markus D Schofer Journal: Knee Surg Sports Traumatol Arthrosc Date: 2011-06-09 Impact factor: 4.342
Authors: Philipp Niemeyer; Jan M Pestka; Peter C Kreuz; Gian M Salzmann; Wolfgang Köstler; Norbert P Südkamp; Matthias Steinwachs Journal: Knee Surg Sports Traumatol Arthrosc Date: 2010-03-27 Impact factor: 4.342
Authors: L Rackwitz; U Schneider; S Andereya; S Siebenlist; J C Reichert; F Fensky; J Arnholdt; J Arnhold; I Löer; R Grossstück; W Zinser; T Barthel; M Rudert; U Nöth Journal: Orthopade Date: 2012-04 Impact factor: 1.087
Authors: Victoria Horbert; Long Xin; Peter Foehr; Olaf Brinkmann; Matthias Bungartz; Rainer H Burgkart; T Graeve; Raimund W Kinne Journal: Cartilage Date: 2018-02-20 Impact factor: 4.634
Authors: Joern Steinhagen; Juergen Bruns; Georg Deuretzbacher; Wolfgang Ruether; Martin Fuerst; Oliver Niggemeyer Journal: Int Orthop Date: 2009-07-22 Impact factor: 3.075