BACKGROUND: Previous reports demonstrate an association between atrial fibrillation (AF) and certain polymorphisms in genes controlling the production of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS). OBJECTIVES: The purpose of this study was to examine the association between polymorphisms of ACE and eNOS gene complexes and AF in an unselected series of patients with congestive heart failure (CHF). METHODS: In each of the 340 unselected, unrelated patients with CHF, common polymorphisms in ACE (I/D) and eNOS (T786C, G894T, and intron 4b/a) gene complexes were evaluated. Associations between individual genotypes and the presence of AF were assayed. RESULTS: AF was present in 51 patients (15%) and was significantly associated with the ACE D/D (odds ratio 1.5) and eNOS 894 T/T genotypes (odds ratio 3.2). There were no significant associations between AF and eNOS 786 or eNOS intron 4 genotypes. CONCLUSION: In patients with CHF, the presence of AF was significantly associated with certain ACE and eNOS genotypes.
BACKGROUND: Previous reports demonstrate an association between atrial fibrillation (AF) and certain polymorphisms in genes controlling the production of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS). OBJECTIVES: The purpose of this study was to examine the association between polymorphisms of ACE and eNOS gene complexes and AF in an unselected series of patients with congestive heart failure (CHF). METHODS: In each of the 340 unselected, unrelated patients with CHF, common polymorphisms in ACE (I/D) and eNOS (T786C, G894T, and intron 4b/a) gene complexes were evaluated. Associations between individual genotypes and the presence of AF were assayed. RESULTS:AF was present in 51 patients (15%) and was significantly associated with the ACE D/D (odds ratio 1.5) and eNOS 894 T/T genotypes (odds ratio 3.2). There were no significant associations between AF and eNOS 786 or eNOS intron 4 genotypes. CONCLUSION: In patients with CHF, the presence of AF was significantly associated with certain ACE and eNOS genotypes.
Authors: Moritz F Sinner; Steven A Lubitz; Arne Pfeufer; Seiko Makino; Britt-Maria Beckmann; Kathryn L Lunetta; Gerhard Steinbeck; Siegfried Perz; Rosanna Rahman; Akshata Sonni; Steven M Greenberg; Karen L Furie; H-Erich Wichmann; Thomas Meitinger; Annette Peters; Emelia J Benjamin; Jonathan Rosand; Patrick T Ellinor; Stefan Kääb Journal: Heart Rhythm Date: 2010-11-04 Impact factor: 6.343
Authors: Saagar Mahida; Steven A Lubitz; Michiel Rienstra; David J Milan; Patrick T Ellinor Journal: Cardiovasc Res Date: 2010-11-30 Impact factor: 10.787
Authors: Paulus Kirchhof; Gregory Y H Lip; Isabelle C Van Gelder; Jeroen Bax; Elaine Hylek; Stefan Kaab; Ulrich Schotten; Karl Wegscheider; Giuseppe Boriani; Axel Brandes; Michael Ezekowitz; Hans Diener; Laurent Haegeli; Hein Heidbuchel; Deirdre Lane; Luis Mont; Stephan Willems; Paul Dorian; Maria Aunes-Jansson; Carina Blomstrom-Lundqvist; Maria Borentain; Stefanie Breitenstein; Martina Brueckmann; Nilo Cater; Andreas Clemens; Dobromir Dobrev; Sergio Dubner; Nils G Edvardsson; Leif Friberg; Andreas Goette; Michele Gulizia; Robert Hatala; Jenny Horwood; Lukas Szumowski; Lukas Kappenberger; Josef Kautzner; Angelika Leute; Trudie Lobban; Ralf Meyer; Jay Millerhagen; John Morgan; Felix Muenzel; Michael Nabauer; Christoph Baertels; Michael Oeff; Dieter Paar; Juergen Polifka; Ursula Ravens; Ludger Rosin; W Stegink; Gerhard Steinbeck; Panos Vardas; Alphons Vincent; Maureen Walter; Günter Breithardt; A John Camm Journal: Europace Date: 2011-07-26 Impact factor: 5.214
Authors: Steven A Lubitz; Cevher Ozcan; Jared W Magnani; Stefan Kääb; Emelia J Benjamin; Patrick T Ellinor Journal: Circ Arrhythm Electrophysiol Date: 2010-06
Authors: Nona Sotoodehnia; Guo Li; Catherine O Johnson; Rozenn N Lemaitre; Kenneth M Rice; Thomas D Rea; David S Siscovick Journal: Heart Rhythm Date: 2009-06-09 Impact factor: 6.343