OBJECTIVE: This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD). METHOD: Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method. RESULTS: The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group. CONCLUSIONS: These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.
OBJECTIVE: This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD). METHOD: Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method. RESULTS: The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group. CONCLUSIONS: These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with ADpatients as well.
Authors: Matthias Brendel; Oliver Pogarell; Guoming Xiong; Andreas Delker; Peter Bartenstein; Axel Rominger Journal: Eur J Nucl Med Mol Imaging Date: 2015-01-29 Impact factor: 9.236
Authors: Tommaso Ballarini; Leonardo Iaccarino; Giuseppe Magnani; Nagehan Ayakta; Bruce L Miller; William J Jagust; Maria Luisa Gorno-Tempini; Gil D Rabinovici; Daniela Perani Journal: Hum Brain Mapp Date: 2016-07-13 Impact factor: 5.038
Authors: Hye Sook Lee; Il Han Choo; Dong Young Lee; Jee Wook Kim; Eun Hyun Seo; Shin Gyeom Kim; Shin Young Park; Ji Hye Shin; Ki Woong Kim; Jong Inn Woo Journal: Psychiatry Investig Date: 2010-08-13 Impact factor: 2.505
Authors: Janina Krell-Roesch; Jeremy A Syrjanen; Maria Vassilaki; Val J Lowe; Prashanthi Vemuri; Michelle M Mielke; Mary M Machulda; Gorazd B Stokin; Teresa J Christianson; Walter K Kremers; Clifford R Jack; David S Knopman; Ronald C Petersen; Yonas E Geda Journal: Am J Geriatr Psychiatry Date: 2020-06-17 Impact factor: 4.105