| Literature DB >> 16815076 |
Vadim Budagian1, Elena Bulanova, Ralf Paus, Silvia Bulfone-Paus.
Abstract
The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance.Entities:
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Year: 2006 PMID： 16815076 DOI： 10.1016/j.cytogfr.2006.05.001
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638