| Literature DB >> 1681266 |
P G Lunn1, C A Northrop-Clewes, R M Downes.
Abstract
There is controversy over whether children in developing countries can catch up on their growth rates after bouts of diarrhoea. A factor influencing catch-up growth is the extent and duration of mucosal injury. To explore the relation between intestinal disease and growth performance, a non-invasive test of intestinal integrity, the lactulose:mannitol permeability test, was done regularly on children aged 2-15 months, whose growth was monitored over a mean of 7.5 months. The study revealed persistent abnormalities in the small bowel mucosa of 2-15 month old Gambian infants and a negative correlation between these abnormalities and growth. Up to 43% of observed growth faltering can be explained on the basis of these long-term intestinal lesions.Entities:
Keywords: Africa; Africa South Of The Sahara; Anthropometry--changes; Biology; Body Weight--changes; Breast Feeding; Child Development; Child Nutrition; Demographic Factors; Developing Countries; Diarrhea; Diarrhea, Infantile; Diseases; English Speaking Africa; Examinations And Diagnoses; Gambia; Gastrointestinal Effects; Growth; Health; Infant Nutrition; Laboratory Examinations And Diagnoses; Longitudinal Studies; Malnutrition; Measurement; Nutrition; Nutrition Disorders; Physiology; Population; Population Characteristics; Prevalence; Prospective Studies; Research Methodology; Rural Population; Studies; Western Africa
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Year: 1991 PMID： 1681266 DOI： 10.1016/0140-6736(91)91772-m
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321