Literature DB >> 16809370

Microarrays and the microscope: balancing throughput with resolution.

Giovanni Coppola1, Daniel H Geschwind.   

Abstract

The cellular complexity of the brain is a major issue in the planning, execution and interpretation of microarray studies. Recent technical advances allow for high-throughput study of specific cell populations and circuits. Here we review representative examples of currently available methods that allow high resolution and specificity in brain microarray studies, while maintaining the goal of comprehensive, high-throughput analysis.

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Year:  2006        PMID： 16809370      PMCID： PMC1819448          DOI： 10.1113/jphysiol.2006.112623

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  66 in total

Review 1.  Single-cell molecular biology.

Authors:  J Eberwine
Journal:  Nat Neurosci       Date:  2001-11       Impact factor: 24.884

2.  A primary culture system for functional analysis of C. elegans neurons and muscle cells.

Authors:  Michael Christensen; Ana Estevez; Xiaoyan Yin; Rebecca Fox; Rebecca Morrison; Maureen McDonnell; Christina Gleason; David M Miller; Kevin Strange
Journal:  Neuron       Date:  2002-02-14       Impact factor: 17.173

3.  DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles.

Authors:  S J Evans; P V Choudary; M P Vawter; J Li; J H Meador-Woodruff; J F Lopez; S M Burke; R C Thompson; R M Myers; E G Jones; W E Bunney; S J Watson; H Akil
Journal:  Neurobiol Dis       Date:  2003-11       Impact factor: 5.996

4.  Selection and validation of microarray candidate genes from subregions and subnuclei of the brain.

Authors:  Mariela Zirlinger
Journal:  Methods       Date:  2003-12       Impact factor: 3.608

5.  Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.

Authors:  Paola Arlotta; Bradley J Molyneaux; Jinhui Chen; Jun Inoue; Ryo Kominami; Jeffrey D Macklis
Journal:  Neuron       Date:  2005-01-20       Impact factor: 17.173

6.  Presenilin-1-dependent transcriptome changes.

Authors:  Károly Mirnics; Zeljka Korade; Dominique Arion; Orly Lazarov; Travis Unger; Melissa Macioce; Michael Sabatini; David Terrano; Katherine C Douglass; Nina F Schor; Sangram S Sisodia
Journal:  J Neurosci       Date:  2005-02-09       Impact factor: 6.167

7.  A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.

Authors:  Shiaoching Gong; Chen Zheng; Martin L Doughty; Kasia Losos; Nicholas Didkovsky; Uta B Schambra; Norma J Nowak; Alexandra Joyner; Gabrielle Leblanc; Mary E Hatten; Nathaniel Heintz
Journal:  Nature       Date:  2003-10-30       Impact factor: 49.962

8.  Identification of ciliated sensory neuron-expressed genes in Caenorhabditis elegans using targeted pull-down of poly(A) tails.

Authors:  Hirofumi Kunitomo; Hiroko Uesugi; Yuji Kohara; Yuichi Iino
Journal:  Genome Biol       Date:  2005-01-31       Impact factor: 13.583

9.  Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.

Authors:  Stephen D Ginsberg; Shaoli Che; Scott E Counts; Elliott J Mufson
Journal:  J Neurochem       Date:  2006-03       Impact factor: 5.372

Review 10.  Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling.

Authors:  Vigdis Nygaard; Eivind Hovig
Journal:  Nucleic Acids Res       Date:  2006-02-09       Impact factor: 16.971
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  3 in total

1.  The mammalian transcriptome and the cellular complexity of the brain.

Authors:  Enrico Cherubini; S Gustincich; H Robinson
Journal:  J Physiol       Date:  2006-08-03       Impact factor: 5.182

Review 2.  Neuroscience in the era of functional genomics and systems biology.

Authors:  Daniel H Geschwind; Genevieve Konopka
Journal:  Nature       Date:  2009-10-15       Impact factor: 49.962

3.  Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system.

Authors:  Joseph D Watson; Shenglong Wang; Stephen E Von Stetina; W Clay Spencer; Shawn Levy; Phillip J Dexheimer; Nurith Kurn; Joe Don Heath; David M Miller
Journal:  BMC Genomics       Date:  2008-02-19       Impact factor: 3.969
  3 in total

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