| Literature DB >> 14586460 |
Shiaoching Gong1, Chen Zheng, Martin L Doughty, Kasia Losos, Nicholas Didkovsky, Uta B Schambra, Norma J Nowak, Alexandra Joyner, Gabrielle Leblanc, Mary E Hatten, Nathaniel Heintz.
Abstract
The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosome (BAC) vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways. We illustrate the use of this atlas to derive novel insights into gene function in neural cells, and into principal steps of CNS development. The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community.Entities:
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Year: 2003 PMID： 14586460 DOI： 10.1038/nature02033
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962