Literature DB >> 16809033

Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties.

Peng Zhou1, Anca Dragulescu-Andrasi, Birendra Bhattacharya, Heather O'Keefe, Paolo Vatta, Jens J Hyldig-Nielsen, Danith H Ly.   

Abstract

Guanidine-based peptide nucleic acid (GPNA) monomers and oligomers containing all four natural (adenine (A), cytosine (C), guanine (G), and thymine (T)) and two unnatural (2-thiouracil (sU) and 2,6-diaminopurine (D)) nucleobases have been synthesized. Thermal denaturation study showed that GPNA oligomers containing alternate D-backbone configuration bind sequence-specifically to DNA and, when incubated with mammalian cells, localized specifically to the endoplasmic reticulum (ER).

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16809033     DOI： 10.1016/j.bmcl.2006.06.052

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Multiple triphenylphosphonium cations as a platform for the delivery of a pro-apoptotic peptide.

Authors:  Netanel Kolevzon; Uriel Kuflik; Miriam Shmuel; Sandrine Benhamron; Israel Ringel; Eylon Yavin
Journal:  Pharm Res       Date:  2011-06-02       Impact factor: 4.200

2.  Recognition of double-stranded RNA by guanidine-modified peptide nucleic acids.

Authors:  Pankaj Gupta; Oluwatoyosi Muse; Eriks Rozners
Journal:  Biochemistry       Date:  2011-12-20       Impact factor: 3.162

Review 3.  Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.

Authors:  Maria Moccia; Mauro F A Adamo; Michele Saviano
Journal:  Artif DNA PNA XNA       Date:  2016-01-11

4.  Improvement of sequence selectivity in triple helical recognition of RNA by phenylalanine-derived PNA.

Authors:  Thomas Zengeya; Artem Gindin; Eriks Rozners
Journal:  Artif DNA PNA XNA       Date:  2013-10-08

5.  Nanoparticle for delivery of antisense γPNA oligomers targeting CCR5.

Authors:  Raman Bahal; Nicole Ali McNeer; Danith H Ly; W Mark Saltzman; Peter M Glazer
Journal:  Artif DNA PNA XNA       Date:  2013 Apr-Jun

6.  β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid.

Authors:  Evan Delgado; Raman Bahal; Jing Yang; Jung M Lee; Danith H Ly; Satdarshan P S Monga
Journal:  Curr Cancer Drug Targets       Date:  2013-10       Impact factor: 3.428

7.  Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.

Authors:  Sufi M Thomas; Bichismita Sahu; Srinivas Rapireddy; Raman Bahal; Sarah E Wheeler; Eva M Procopio; Joseph Kim; Sonali C Joyce; Sarah Contrucci; Yun Wang; Simion I Chiosea; Kira L Lathrop; Simon Watkins; Jennifer R Grandis; Bruce A Armitage; Danith H Ly
Journal:  ACS Chem Biol       Date:  2012-11-09       Impact factor: 5.100

8.  Synthesis of conformationally preorganized and cell-permeable guanidine-based gamma-peptide nucleic acids (gammaGPNAs).

Authors:  Bichismita Sahu; Venugopal Chenna; Kira L Lathrop; Sufi M Thomas; Gerald Zon; Kenneth J Livak; Danith H Ly
Journal:  J Org Chem       Date:  2009-02-20       Impact factor: 4.354

9.  Recent advances in chemical modification of Peptide nucleic acids.

Authors:  Eriks Rozners
Journal:  J Nucleic Acids       Date:  2012-09-06

10.  Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation.

Authors:  Concetta Avitabile; Michele Saviano; Luca D'Andrea; Nicoletta Bianchi; Enrica Fabbri; Eleonora Brognara; Roberto Gambari; Alessandra Romanelli
Journal:  Artif DNA PNA XNA       Date:  2012-04-01
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.