Mei Lu1, A B M Rabie. 1. Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Abstract
OBJECTIVE: To explore the relationship between bone resorption and matrix metalloproteinase-9 (MMP-9) expression in autogenous and allogenic bone grafts. MATERIALS AND METHODS: A total of 18 critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Three groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, and allogenic IM bone. Three months later, the defects were retrieved for quantitative analysis on the basis of histology, immunohistochemistry, and in situ hybridization. RESULTS: A close relationship existed between MMP-9 expression and graft bone resorption. The parallel between MMP-9 expression and graft bone resorption suggested that bone resorption was accomplished in part by increased MMP-9 production evident in preosteoclasts and osteoclasts. CONCLUSIONS: MMP-9 plays an important role in graft bone resorption. Autogenous EC bone grafts express higher levels of MMP-9 leading to more resorption than autogenous or allogenic IM bone grafts.
OBJECTIVE: To explore the relationship between bone resorption and matrix metalloproteinase-9 (MMP-9) expression in autogenous and allogenic bone grafts. MATERIALS AND METHODS: A total of 18 critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Three groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, and allogenic IM bone. Three months later, the defects were retrieved for quantitative analysis on the basis of histology, immunohistochemistry, and in situ hybridization. RESULTS: A close relationship existed between MMP-9 expression and graft bone resorption. The parallel between MMP-9 expression and graft bone resorption suggested that bone resorption was accomplished in part by increased MMP-9 production evident in preosteoclasts and osteoclasts. CONCLUSIONS:MMP-9 plays an important role in graft bone resorption. Autogenous EC bone grafts express higher levels of MMP-9 leading to more resorption than autogenous or allogenic IM bone grafts.
Authors: Jeffry S Nyman; Conor C Lynch; Daniel S Perrien; Sophie Thiolloy; Elizabeth C O'Quinn; Chetan A Patil; Xiaohong Bi; George M Pharr; Anita Mahadevan-Jansen; Gregory R Mundy Journal: J Bone Miner Res Date: 2011-06 Impact factor: 6.741
Authors: Ayelén Ivana Pesce Viglietti; Paula Constanza Arriola Benitez; María Virginia Gentilini; Lis Noelia Velásquez; Carlos Alberto Fossati; Guillermo Hernán Giambartolomei; María Victoria Delpino Journal: Infect Immun Date: 2015-10-12 Impact factor: 3.441