| Literature DB >> 16800731 |
Astrid K Whitbread1, Tara L Veveris-Lowe, Mitchell G Lawrence, David L Nicol, Judith A Clements.
Abstract
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.Entities:
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Year: 2006 PMID： 16800731 DOI： 10.1515/BC.2006.089
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915