Literature DB >> 16797988

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Kamalika Moulick1, Cristina C Clement, Julia Aguirre, Joungnam Kim, Yanlong Kang, Sara Felts, Gabriela Chiosis.   

Abstract

The synthesis of a red-shifted cy3B-GM ligand and its evaluation as a fluorescence polarization probe for Hsp90 is presented.

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Year:  2006        PMID： 16797988     DOI： 10.1016/j.bmcl.2006.06.025

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

1.  Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

Authors:  Pallav D Patel; Pengrong Yan; Paul M Seidler; Hardik J Patel; Weilin Sun; Chenghua Yang; Nanette S Que; Tony Taldone; Paola Finotti; Ralph A Stephani; Daniel T Gewirth; Gabriela Chiosis
Journal:  Nat Chem Biol       Date:  2013-09-01       Impact factor: 15.040

2.  Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.

Authors:  Hardik J Patel; Pallav D Patel; Stefan O Ochiana; Pengrong Yan; Weilin Sun; Maulik R Patel; Smit K Shah; Elisa Tramentozzi; James Brooks; Alexander Bolaender; Liza Shrestha; Ralph Stephani; Paola Finotti; Cynthia Leifer; Zihai Li; Daniel T Gewirth; Tony Taldone; Gabriela Chiosis
Journal:  J Med Chem       Date:  2015-04-22       Impact factor: 7.446

3.  The epichaperome is an integrated chaperome network that facilitates tumour survival.

Authors:  Anna Rodina; Tai Wang; Pengrong Yan; Erica DaGama Gomes; Mark P S Dunphy; Nagavarakishore Pillarsetty; John Koren; John F Gerecitano; Tony Taldone; Hongliang Zong; Eloisi Caldas-Lopes; Mary Alpaugh; Adriana Corben; Matthew Riolo; Brad Beattie; Christina Pressl; Radu I Peter; Chao Xu; Robert Trondl; Hardik J Patel; Fumiko Shimizu; Alexander Bolaender; Chenghua Yang; Palak Panchal; Mohammad F Farooq; Sarah Kishinevsky; Shanu Modi; Oscar Lin; Feixia Chu; Sujata Patil; Hediye Erdjument-Bromage; Pat Zanzonico; Clifford Hudis; Lorenz Studer; Gail J Roboz; Ethel Cesarman; Leandro Cerchietti; Ross Levine; Ari Melnick; Steven M Larson; Jason S Lewis; Monica L Guzman; Gabriela Chiosis
Journal:  Nature       Date:  2016-10-05       Impact factor: 49.962

4.  Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.

Authors:  Iwona E Wrona; Alexander Gozman; Tony Taldone; Gabriela Chiosis; James S Panek
Journal:  J Org Chem       Date:  2010-05-07       Impact factor: 4.354

5.  Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.

Authors:  Tony Taldone; Erica M Gomes-DaGama; Hongliang Zong; Siddhartha Sen; Mary L Alpaugh; Danuta Zatorska; Raul Alonso-Sabadell; Monica L Guzman; Gabriela Chiosis
Journal:  Bioorg Med Chem Lett       Date:  2011-07-14       Impact factor: 2.823

6.  Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

Authors:  Tony Taldone; Victoria Gillan; Weilin Sun; Anna Rodina; Pallav Patel; Kirsty Maitland; Kerry O'Neill; Gabriela Chiosis; Eileen Devaney
Journal:  PLoS Negl Trop Dis       Date:  2010-06-15

7.  Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.

Authors:  Anna Rodina; Pallav D Patel; Yanlong Kang; Yogita Patel; Imad Baaklini; Michael J H Wong; Tony Taldone; Pengrong Yan; Chenghua Yang; Ronnie Maharaj; Alexander Gozman; Maulik R Patel; Hardik J Patel; William Chirico; Hediye Erdjument-Bromage; Tanaji T Talele; Jason C Young; Gabriela Chiosis
Journal:  Chem Biol       Date:  2013-11-14

8.  Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.

Authors:  Thota Ganesh; Jaeki Min; Pahk Thepchatri; Yuhong Du; Lian Li; Iestyn Lewis; Larry Wilson; Haian Fu; Gabriela Chiosis; Raymond Dingledine; Dennis Liotta; James P Snyder; Aiming Sun
Journal:  Bioorg Med Chem       Date:  2008-05-27       Impact factor: 3.641

9.  Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.

Authors:  Tony Taldone; Pallav D Patel; Maulik Patel; Hardik J Patel; Christopher E Evans; Anna Rodina; Stefan Ochiana; Smit K Shah; Mohammad Uddin; Daniel Gewirth; Gabriela Chiosis
Journal:  J Med Chem       Date:  2013-08-21       Impact factor: 7.446

10.  Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs.

Authors:  Dany Pechalrieu; Fanny Assemat; Ludovic Halby; Marlene Marcellin; Pengrong Yan; Karima Chaoui; Sahil Sharma; Gabriela Chiosis; Odile Burlet-Schiltz; Paola B Arimondo; Marie Lopez
Journal:  ACS Chem Biol       Date:  2020-04-06       Impact factor: 5.100
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