Literature DB >> 16797777

When transcription and repair meet: a complex system.

Jean-Philippe Lainé1, Jean-Marc Egly.   

Abstract

Transcription-coupled repair (TCR) is a mechanism that removes DNA lesions so that genes can be transcribed correctly. However, the sequence of events that results in a DNA lesion being repaired remains elusive. In this review, we illustrate the potential chain of events leading to the elimination of the damaged DNA and the proper resumption of transcription. We focus on the roles of CSA and CSB proteins, which, when mutated, impair TCR. Defective TCR is one of the features of Cockayne syndrome, a DNA-repair disorder.

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Year:  2006        PMID： 16797777     DOI： 10.1016/j.tig.2006.06.006

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  61 in total

1.  Cockayne syndrome, underlying molecular defects and p53.

Authors:  Brian R Berquist; Vilhelm A Bohr
Journal:  Cell Cycle       Date:  2011-12-01       Impact factor: 4.534

Review 2.  Nucleotide excision repair deficient mouse models and neurological disease.

Authors:  Laura J Niedernhofer
Journal:  DNA Repair (Amst)       Date:  2008-02-12

3.  Mechanism of T7 RNAP pausing and termination at the T7 concatemer junction: a local change in transcription bubble structure drives a large change in transcription complex architecture.

Authors:  Dhananjaya Nayak; Sylvester Siller; Qing Guo; Rui Sousa
Journal:  J Mol Biol       Date:  2007-12-04       Impact factor: 5.469

Review 4.  Mechanisms for ATP-dependent chromatin remodelling: the means to the end.

Authors:  Andrew Flaus; Tom Owen-Hughes
Journal:  FEBS J       Date:  2011-09-08       Impact factor: 5.542

Review 5.  Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases.

Authors:  Ivona Brasnjevic; Patrick R Hof; Harry W M Steinbusch; Christoph Schmitz
Journal:  DNA Repair (Amst)       Date:  2008-05-23

Review 6.  DNA repair deficiency and neurological disease.

Authors:  Peter J McKinnon
Journal:  Nat Rev Neurosci       Date:  2009-01-15       Impact factor: 34.870

7.  Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Authors:  Anwaar Ahmad; Jacqueline H Enzlin; Nikhil R Bhagwat; Nils Wijgers; Anja Raams; Esther Appledoorn; Arjan F Theil; Jan H J Hoeijmakers; Wim Vermeulen; Nicolaas G J Jaspers; Orlando D Schärer; Laura J Niedernhofer
Journal:  PLoS Genet       Date:  2010-03-05       Impact factor: 5.917

8.  A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.

Authors:  Roy Anindya; Pierre-Olivier Mari; Ulrik Kristensen; Hanneke Kool; Giuseppina Giglia-Mari; Leon H Mullenders; Maria Fousteri; Wim Vermeulen; Jean-Marc Egly; Jesper Q Svejstrup
Journal:  Mol Cell       Date:  2010-06-11       Impact factor: 17.970

9.  Rpb1 sumoylation in response to UV radiation or transcriptional impairment in yeast.

Authors:  Xuefeng Chen; Baojin Ding; Danielle LeJeune; Christine Ruggiero; Shisheng Li
Journal:  PLoS One       Date:  2009-04-22       Impact factor: 3.240

10.  INTS3 controls the hSSB1-mediated DNA damage response.

Authors:  Jeffrey R Skaar; Derek J Richard; Anita Saraf; Alfredo Toschi; Emma Bolderson; Laurence Florens; Michael P Washburn; Kum Kum Khanna; Michele Pagano
Journal:  J Cell Biol       Date:  2009-09-28       Impact factor: 10.539
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