OBJECTIVE: We investigated the effects on occipital cortex, of two newly developed methods of repetitive transcranial magnetic stimulation (rTMS): continuous and intermittent theta burst stimulation (cTBS and iTBS), that lead to long lasting changes in excitability when applied over primary motor cortex. METHODS: Phosphene threshold to a single TMS pulse was measured before and after application of either continuous or intermittent theta burst stimulation (cTBS/iTBS; 600 total pulses at 80% phosphene threshold). RESULTS: In our cohort, cTBS increased phosphene threshold by an average of 10%. In contrast, iTBS, which transiently increases motor cortex excitability, had no effect on phosphene threshold. CONCLUSIONS: cTBS can be applied successfully to non-motor areas of cortex, but iTBS may need modification to produce maximal effects. SIGNIFICANCE: cTBS maybe a new useful tool in disorders characterized by an abnormal state of activity of the visual cortex.
OBJECTIVE: We investigated the effects on occipital cortex, of two newly developed methods of repetitive transcranial magnetic stimulation (rTMS): continuous and intermittent theta burst stimulation (cTBS and iTBS), that lead to long lasting changes in excitability when applied over primary motor cortex. METHODS: Phosphene threshold to a single TMS pulse was measured before and after application of either continuous or intermittent theta burst stimulation (cTBS/iTBS; 600 total pulses at 80% phosphene threshold). RESULTS: In our cohort, cTBS increased phosphene threshold by an average of 10%. In contrast, iTBS, which transiently increases motor cortex excitability, had no effect on phosphene threshold. CONCLUSIONS:cTBS can be applied successfully to non-motor areas of cortex, but iTBS may need modification to produce maximal effects. SIGNIFICANCE: cTBS maybe a new useful tool in disorders characterized by an abnormal state of activity of the visual cortex.
Authors: Berthold Langguth; Tobias Kleinjung; Elmar Frank; Michael Landgrebe; Philipp Sand; Jana Dvorakova; Ulrich Frick; Peter Eichhammer; Göran Hajak Journal: Exp Brain Res Date: 2007-12-07 Impact factor: 1.972
Authors: Dirk De Ridder; Elsa van der Loo; Karolien Van der Kelen; Tomas Menovsky; Paul van de Heyning; Aage Moller Journal: Int J Med Sci Date: 2007-10-09 Impact factor: 3.738