Literature DB >> 16794263

Concise review: scientific and ethical roadblocks to human embryonic stem cell therapy.

Lori Gruen1, Laura Grabel.   

Abstract

Despite the identified therapeutic potential of embryonic stem cells for treating human disease and injury, a number of roadblocks, scientific and ethical, stand in the way of progress toward this goal. We identify six areas of particular interest: tumorigenicity, animal product contamination, genetic compatibility, funding, cell type for transplantation, "embryo-friendly" derivation methods and discuss avenues for moving beyond the difficulties.

Entities:  

Mesh：

Year:  2006        PMID： 16794263     DOI： 10.1634/stemcells.2006-0105

Source DB:  PubMed          Journal:  Stem Cells        ISSN： 1066-5099            Impact factor:   6.277


  17 in total

1.  Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation.

Authors:  Eileen Gentleman; Robin J Swain; Nicholas D Evans; Suwimon Boonrungsiman; Gavin Jell; Michael D Ball; Tamaryn A V Shean; Michelle L Oyen; Alexandra Porter; Molly M Stevens
Journal:  Nat Mater       Date:  2009-07-26       Impact factor: 43.841

2.  The ethics of moral compromise for stem cell research policy.

Authors:  Zubin Master; G K D Crozier
Journal:  Health Care Anal       Date:  2012-03

3.  Sonic Hedgehog Effectively Improves Oct4-Mediated Reprogramming of Astrocytes into Neural Stem Cells.

Authors:  Hao Yang; Cuicui Liu; Hong Fan; Bo Chen; Dageng Huang; Lingling Zhang; Qian Zhang; Jing An; Jingjing Zhao; Yi Wang; Dingjun Hao
Journal:  Mol Ther       Date:  2019-05-16       Impact factor: 11.454

4.  Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.

Authors:  Jiahai Shi; Lenka Kundrat; Novalia Pishesha; Angelina Bilate; Chris Theile; Takeshi Maruyama; Stephanie K Dougan; Hidde L Ploegh; Harvey F Lodish
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-30       Impact factor: 11.205

5.  Efficient Generation of Functionally Active Spinal Cord Neurons from Spermatogonial Stem Cells.

Authors:  Hao Yang; Cuicui Liu; Bo Chen; Jing An; Rui Zhang; Qian Zhang; Jingjing Zhao; Baorong He; Ding-Jun Hao
Journal:  Mol Neurobiol       Date:  2016-08-26       Impact factor: 5.590

Review 6.  Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy.

Authors:  Janice R Naegele; Xu Maisano; Jia Yang; Sara Royston; Efrain Ribeiro
Journal:  Neuropharmacology       Date:  2010-02-08       Impact factor: 5.250

Review 7.  Stem cell paracrine actions and tissue regeneration.

Authors:  Priya R Baraniak; Todd C McDevitt
Journal:  Regen Med       Date:  2010-01       Impact factor: 3.806

8.  Transcriptional characterization of the Notch signaling pathway in rodent multipotent adult progenitor cells.

Authors:  Melinda Hajdu; Aernout Luttun; Beatriz Pelacho; Terry C Burns; Lucas Chase; María Gutiérrez-Pérez; Yuehua Jiang; Todd Lenvik; Virág Vas; Ferenc Uher; Anna Sebestyén; Catherine Verfaillie
Journal:  Pathol Oncol Res       Date:  2007-12-25       Impact factor: 3.201

Review 9.  Empowering Adult Stem Cells for Myocardial Regeneration V2.0: Success in Small Steps.

Authors:  Kathleen M Broughton; Mark A Sussman
Journal:  Circ Res       Date:  2016-03-04       Impact factor: 17.367

10.  Evaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter.

Authors:  Ahmi Ben-Yehudah; Carlie White; Christopher S Navara; Carlos A Castro; Diego Ize-Ludlow; Benjamin Shaffer; Meena Sukhwani; Clayton E Mathews; J Richard Chaillet; Selma F Witchel
Journal:  Cloning Stem Cells       Date:  2009-06
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