Literature DB >> 20146928

Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy.

Janice R Naegele1, Xu Maisano, Jia Yang, Sara Royston, Efrain Ribeiro.   

Abstract

The potential applications of stem cell therapies for treating neurological disorders are enormous. Many laboratories are focusing on stem cell treatments for CNS diseases, including spinal cord injury, Amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, stroke, traumatic brain injury, and epilepsy. Among the many stem cell types under testing for neurological treatments, the most common are fetal and adult brain stem cells, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells. An expanding toolbox of molecular probes is now available to allow analyses of neural stem cell fates prior to and after transplantation. Concomitantly, protocols are being developed to direct the fates of stem cell-derived neural progenitors, and also to screen stem cells for tumorigenicity and aneuploidy. The rapid progress in the field suggests that novel stem cell and gene therapies for neurological disorders are in the pipeline. Copyright 2010 Elsevier Ltd. All rights reserved.

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Mesh：

Year:  2010        PMID： 20146928      PMCID： PMC2838966          DOI： 10.1016/j.neuropharm.2010.01.019

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  149 in total

1.  The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations.

Authors:  Susana Nery; Gord Fishell; Joshua G Corbin
Journal:  Nat Neurosci       Date:  2002-12       Impact factor: 24.884

Review 2.  Directing the differentiation of embryonic stem cells to neural stem cells.

Authors:  Chunyu Cai; Laura Grabel
Journal:  Dev Dyn       Date:  2007-12       Impact factor: 3.780

Review 3.  Human stem cell grafts as therapies for motor neuron disease.

Authors:  Vassilis E Koliatsos; Leyan Xu; Jun Yan
Journal:  Expert Opin Biol Ther       Date:  2008-02       Impact factor: 4.388

4.  Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis.

Authors:  Tianfu Li; Gaoying Ren; David L Kaplan; Detlev Boison
Journal:  Epilepsy Res       Date:  2009-02-12       Impact factor: 3.045

5.  Hippocampal grafts into the intact brain induce epileptic patterns.

Authors:  G Buzsáki; E Masliah; L S Chen; Z Horváth; R Terry; F H Gage
Journal:  Brain Res       Date:  1991-07-19       Impact factor: 3.252

6.  Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence.

Authors:  M Olsson; A Björklund; K Campbell
Journal:  Neuroscience       Date:  1998-06       Impact factor: 3.590

7.  Intracephalic embryonic neural implants in the adult rat brain. I. Growth and mature organization of brainstem, cerebellar, and hippocampal implants.

Authors:  L F Kromer; A Björklund; U Stenevi
Journal:  J Comp Neurol       Date:  1983-08-20       Impact factor: 3.215

8.  Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry.

Authors:  Leyan Xu; David K Ryugo; Tan Pongstaporn; Karl Johe; Vassilis E Koliatsos
Journal:  J Comp Neurol       Date:  2009-06-01       Impact factor: 3.215

9.  Derivation of homogeneous GABAergic neurons from mouse embryonic stem cells.

Authors:  Christina Chatzi; Roderick H Scott; Jin Pu; Bing Lang; Chizu Nakamoto; Colin D McCaig; Sanbing Shen
Journal:  Exp Neurol       Date:  2009-04-05       Impact factor: 5.330

10.  Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats.

Authors:  Lee A Shapiro; Lulu Wang; Charles E Ribak
Journal:  Epilepsia       Date:  2008       Impact factor: 5.864
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  21 in total

Review 1.  Stem cells as a potential therapy for epilepsy.

Authors:  Steven N Roper; Dennis A Steindler
Journal:  Exp Neurol       Date:  2012-01-13       Impact factor: 5.330

Review 2.  Neuroprotection for amyotrophic lateral sclerosis: role of stem cells, growth factors, and gene therapy.

Authors:  Rachna S Pandya; Lilly L J Mao; Edward W Zhou; Robert Bowser; Zhenglun Zhu; Yongjin Zhu; Xin Wang
Journal:  Cent Nerv Syst Agents Med Chem       Date:  2012-03

Review 3.  Induced pluripotent stem cells: a new tool to confront the challenge of neuropsychiatric disorders.

Authors:  Flora M Vaccarino; Hanna E Stevens; Arif Kocabas; Dean Palejev; Anna Szekely; Elena L Grigorenko; Sherman Weissman
Journal:  Neuropharmacology       Date:  2011-03-01       Impact factor: 5.250

Review 4.  GABAergic interneuron transplants to study development and treat disease.

Authors:  Jennifer A Tyson; Stewart A Anderson
Journal:  Trends Neurosci       Date:  2014-02-07       Impact factor: 13.837

Review 5.  Annual Research Review: The promise of stem cell research for neuropsychiatric disorders.

Authors:  Flora M Vaccarino; Alexander Eckehart Urban; Hanna E Stevens; Anna Szekely; Alexej Abyzov; Elena L Grigorenko; Mark Gerstein; Sherman Weissman
Journal:  J Child Psychol Psychiatry       Date:  2011-01-04       Impact factor: 8.982

6.  Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy.

Authors:  Xu Maisano; Elizabeth Litvina; Stephanie Tagliatela; Gloster B Aaron; Laura B Grabel; Janice R Naegele
Journal:  J Neurosci       Date:  2012-01-04       Impact factor: 6.167

7.  Subventricular zone-derived neural stem cell grafts protect against hippocampal degeneration and restore cognitive function in the mouse following intrahippocampal kainic acid administration.

Authors:  Panagiota Miltiadous; Georgia Kouroupi; Antonios Stamatakis; Paraskevi N Koutsoudaki; Rebecca Matsas; Fotini Stylianopoulou
Journal:  Stem Cells Transl Med       Date:  2013-02-15       Impact factor: 6.940

Review 8.  Epilepsy and epileptic syndrome.

Authors:  Tomonori Ono; Aristea S Galanopoulou
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

Review 9.  Stem Cells in Neurological Disorders: Emerging Therapy with Stunning Hopes.

Authors:  Ghanshyam Upadhyay; Sharmila Shankar; Rakesh K Srivastava
Journal:  Mol Neurobiol       Date:  2014-09-23       Impact factor: 5.590

Review 10.  A Molecular Approach to Epilepsy Management: from Current Therapeutic Methods to Preconditioning Efforts.

Authors:  Elham Amini; Mohsen Rezaei; Norlinah Mohamed Ibrahim; Mojtaba Golpich; Rasoul Ghasemi; Zahurin Mohamed; Azman Ali Raymond; Leila Dargahi; Abolhassan Ahmadiani
Journal:  Mol Neurobiol       Date:  2014-09-09       Impact factor: 5.590
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