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Literature DB >> 16793009

Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice.

Hitoshi Ando¹, Yasuo Oshima, Hayato Yanagihara, Yohei Hayashi, Toshinari Takamura, Shuichi Kaneko, Akio Fujimura.

Abstract

Although a number of genes expressed in most tissues, including the liver, exhibit circadian regulation, gene expression profiles are usually examined only at one scheduled time each day. In this study, we investigated the effects of obese diabetes on the hepatic mRNA levels of various genes at 6-h intervals over a single 24-h period. Microarray analysis revealed that many genes are expressed rhythmically, not only in control KK mice but also in obese diabetic KK-A(y) mice. Real-time quantitative PCR verified that 19 of 23 putative circadianly expressed genes showed significant 24-h rhythmicity in both strains. However, obese diabetes attenuated these expression rhythms in 10 of 19 genes. More importantly, the effects of obese diabetes were observed throughout the day in only two genes. These results suggest that observation time influences the results of gene expression analyses of genes expressed circadianly.

Entities: Disease Gene Species

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Year: 2006 PMID： 16793009 DOI： 10.1016/j.bbrc.2006.06.044

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

12 in total

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4. Effects of dietary sea cucumber saponin on the gene expression rhythm involved in circadian clock and lipid metabolism in mice during nighttime-feeding.

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Journal: J Physiol Biochem Date: 2014-07-26 Impact factor: 4.158

10. Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism.

Authors: Yuta Fuse; Akiko Hirao; Hiroaki Kuroda; Makiko Otsuka; Yu Tahara; Shigenobu Shibata
Journal: J Circadian Rhythms Date: 2012-05-15

Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice.

Review 1. Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action.

2. Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding.

3. Estimating time of death based on the biological clock.

4. Effects of dietary sea cucumber saponin on the gene expression rhythm involved in circadian clock and lipid metabolism in mice during nighttime-feeding.

Review 5. Clock genes, intestinal transport and plasma lipid homeostasis.

6. Circadian rhythm of clock genes in human adipose explants.

7. Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.

Review 8. Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.

9. Discovery of metabolite biomarkers: flux analysis and reaction-reaction network approach.

10. Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism.