Literature DB >> 16792406

Antifungal azaphilones from the fungus Chaetomium cupreum CC3003.

Somdej Kanokmedhakul1, Kwanjai Kanokmedhakul, Pitak Nasomjai, Sysavad Louangsysouphanh, Kasem Soytong, Minoru Isobe, Palangpon Kongsaeree, Samran Prabpai, Apichart Suksamrarn.   

Abstract

Three new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50 values of 10.5, 16.7, 24.3, and 0.6 microg/mL, respectively.

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Year:  2006        PMID： 16792406     DOI： 10.1021/np060051v

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

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2.  Arcopilus eremanthusum sp. nov. as sources of antibacterial and antioxidant metabolites.

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3.  A simple and mild synthesis of 1H-isochromenes and (Z)-1-alkylidene-1,3-dihydroisobenzofurans by the iodocyclization of 2-(1-alkynyl)benzylic alcohols.

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Journal:  J Org Chem       Date:  2010-02-05       Impact factor: 4.354

4.  Efficacy of some natural compounds as antifungal agents.

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Journal:  Pharmacogn Rev       Date:  2012-07

5.  Phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites.

Authors:  Jutta Wiese; Birgit Ohlendorf; Martina Blümel; Rolf Schmaljohann; Johannes F Imhoff
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6.  Biological Control of Phytophthora palmivora Causing Root Rot of Pomelo Using Chaetomium spp.

Authors:  Phung Manh Hung; Pongnak Wattanachai; Soytong Kasem; Supatta Poaim
Journal:  Mycobiology       Date:  2015-03-31       Impact factor: 1.858

7.  Biological Evaluation of Endophytic Fungus Chaetomium sp. NF15 of Justicia adhatoda L.: A Potential Candidate for Drug Discovery.

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Journal:  Jundishapur J Microbiol       Date:  2016-06-05       Impact factor: 0.747

8.  Antimicrobial Metabolites Produced by Penicillium mallochii CCH01 Isolated From the Gut of Ectropis oblique, Cultivated in the Presence of a Histone Deacetylase Inhibitor.

Authors:  Shuxiang Zhang; Han Fang; Caiping Yin; Chaoling Wei; Jingwei Hu; Yinglao Zhang
Journal:  Front Microbiol       Date:  2019-10-02       Impact factor: 5.640

9.  Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora.

Authors:  G R Nalin Rathnayake; N Savitri Kumar; Lalith Jayasinghe; Hiroshi Araya; Yoshinori Fujimoto
Journal:  Nat Prod Bioprospect       Date:  2019-11-15

10.  Efficacy of Chaetomium Species as Biological Control Agents against Phytophthora nicotianae Root Rot in Citrus.

Authors:  Phung Manh Hung; Pongnak Wattanachai; Soytong Kasem; Supattra Poeaim
Journal:  Mycobiology       Date:  2015-09-30       Impact factor: 1.858
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