Literature DB >> 16790810

Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages.

Olaf Scheel1, Martin Papavlassopoulos, Rikard Blunck, Andreas Gebert, Thomas Hartung, Ulrich Zähringer, Ulrich Seydel, Andra B Schromm.   

Abstract

Performing patch-clamp experiments on human macrophages, we show that the K(+) channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for functional association of the MaxiK channel and TLR signaling complexes.

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Year:  2006        PMID: 16790810      PMCID: PMC1489701          DOI: 10.1128/IAI.01783-05

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  14 in total

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2.  A K+ channel is involved in LPS signaling.

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10.  Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.

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6.  Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia.

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