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Literature DB >> 16788788

[Advancement of PET and PET/CT in prostate carcinoma].

Abstract

Functional imaging of prostate carcinoma was examined with the metabolic substrates 2-(18)F-fluorodeoxyglucose, (11)C-methionine, (18)F-fluorodihydrotestosterone, (11)C-acetate and (11)C/(18)F-choline. Based on upregulated enzymes of phospholipid metabolism in prostate carcinoma, (11)C/(18)F-choline is preferentially incorporated into phosphatidylcholine of membrane lipids of prostate cancer cells. PET allows sensitive detection of the (11)C/(18)F-choline signal and PET/CT fusion imaging enables intraprostatic signal localisation. Most published studies report a high detection rate of prostate carcinoma with (11)C/(18)F-choline PET/CT. Differentiation of prostate carcinoma from benign hyperplasia and from focal chronic prostatitis may be difficult; acute prostatitis accumulates (11)C/(18)F-choline with an intensity comparable to prostate carcinoma.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2006 PMID： 16788788 DOI： 10.1007/s00120-006-1088-5

Source DB: PubMed Journal: Urologe A ISSN： 0340-2592 Impact factor: 0.639

29 in total

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Authors: Jenalle D Chandler; Elizabeth D Williams; John L Slavin; James D Best; Suzanne Rogers
Journal: Cancer Date: 2003-04-15 Impact factor: 6.860

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Journal: J Nucl Med Date: 2002-01 Impact factor: 10.057

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Journal: Cancer Res Date: 2001-01-01 Impact factor: 12.701

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Authors: Daniel T Schmid; Hubert John; Roland Zweifel; Tibor Cservenyak; Gerrit Westera; Gerhard W Goerres; Gustav K von Schulthess; Thomas F Hany
Journal: Radiology Date: 2005-05 Impact factor: 11.105

7. Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

Authors: Johannes V Swinnen; Paul P Van Veldhoven; Leen Timmermans; Ellen De Schrijver; Koen Brusselmans; Frank Vanderhoydonc; Tine Van de Sande; Hannelore Heemers; Walter Heyns; Guido Verhoeven
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8. Combined endorectal and phased-array MRI in the prediction of pelvic lymph node metastasis in prostate cancer.

Authors: Liang Wang; Hedvig Hricak; Michael W Kattan; Lawrence H Schwartz; Steven C Eberhardt; Hui-Ni Chen; Peter T Scardino
Journal: AJR Am J Roentgenol Date: 2006-03 Impact factor: 3.959

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Journal: J Steroid Biochem Mol Biol Date: 1998-04 Impact factor: 4.292

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Journal: J Nucl Med Date: 1995-09 Impact factor: 10.057

5 in total

1. Intensity-modulated radiotherapy for prostate cancer implementing molecular imaging with 18F-choline PET-CT to define a simultaneous integrated boost.

Authors: Michael Pinkawa; Richard Holy; Marc D Piroth; Jens Klotz; Sandra Nussen; Thomas Krohn; Felix M Mottaghy; Martin Weibrecht; Michael J Eble
Journal: Strahlenther Onkol Date: 2010-09-30 Impact factor: 3.621