CONTEXT: Brain-derived neurotrophic factor (BDNF) and its receptor appear to be important components of the leptin-signaling cascade involved in energy homeostasis, and mice with BDNF or TrkB gene haploinsufficiency have excessive adiposity. Little is known about the relationship between adiposity and BDNF, particularly in children. OBJECTIVE: The objective of the study was to study the association of serum BDNF with measures of adiposity in children. DESIGN/SETTING/PATIENTS: BDNF was determined by a sandwich-type ELISA after an overnight fast in convenience sample of 328 subjects, aged 3-19 yr enriched for extreme obesity. In 43, BDNF was also measured before, and again 1 h after, consuming a high-energy content (787 kcal) milkshake. MAIN OUTCOME MEASURES: Measures included associations between BDNF and measures of adiposity. RESULTS: There were no significant univariate associations between log BDNF and adiposity measured by body mass index (BMI), BMI-Z score, or fat mass. However, in an analysis of covariance accounting for age, sex, race, pubertal status, and platelet count, BDNF was lower in overweight children (mean +/- sd, 39.8 +/- 24.8 vs. 47.0 +/- 25.4 ng/dl, P = 0.03); in multiple regression analyses with log BDNF as the dependent variable, BMI (P = 0.03), BMI-Z (P = 0.01), and body fat (P < 0.02) were all negatively associated with BDNF once age, pubertal status, and platelet count were included in the model. Ingestion of a meal did not significantly alter serum BDNF 1 h later (P = 0.26). CONCLUSIONS: Serum BDNF is lower in extremely overweight children and adolescents than those of normal weight. It remains to be determined whether obese individuals with low serum BDNF for age and platelet count have mutations that alter BDNF function.
CONTEXT: Brain-derived neurotrophic factor (BDNF) and its receptor appear to be important components of the leptin-signaling cascade involved in energy homeostasis, and mice with BDNF or TrkB gene haploinsufficiency have excessive adiposity. Little is known about the relationship between adiposity and BDNF, particularly in children. OBJECTIVE: The objective of the study was to study the association of serum BDNF with measures of adiposity in children. DESIGN/SETTING/PATIENTS: BDNF was determined by a sandwich-type ELISA after an overnight fast in convenience sample of 328 subjects, aged 3-19 yr enriched for extreme obesity. In 43, BDNF was also measured before, and again 1 h after, consuming a high-energy content (787 kcal) milkshake. MAIN OUTCOME MEASURES: Measures included associations between BDNF and measures of adiposity. RESULTS: There were no significant univariate associations between log BDNF and adiposity measured by body mass index (BMI), BMI-Z score, or fat mass. However, in an analysis of covariance accounting for age, sex, race, pubertal status, and platelet count, BDNF was lower in overweight children (mean +/- sd, 39.8 +/- 24.8 vs. 47.0 +/- 25.4 ng/dl, P = 0.03); in multiple regression analyses with log BDNF as the dependent variable, BMI (P = 0.03), BMI-Z (P = 0.01), and body fat (P < 0.02) were all negatively associated with BDNF once age, pubertal status, and platelet count were included in the model. Ingestion of a meal did not significantly alter serum BDNF 1 h later (P = 0.26). CONCLUSIONS: Serum BDNF is lower in extremely overweight children and adolescents than those of normal weight. It remains to be determined whether obese individuals with low serum BDNF for age and platelet count have mutations that alter BDNF function.
Authors: Baoji Xu; Evan H Goulding; Keling Zang; David Cepoi; Roger D Cone; Kevin R Jones; Laurence H Tecott; Louis F Reichardt Journal: Nat Neurosci Date: 2003-07 Impact factor: 24.884
Authors: Marian Tanofsky-Kraff; Susan Z Yanovski; Denise E Wilfley; Cheri Marmarosh; Christina M Morgan; Jack A Yanovski Journal: J Consult Clin Psychol Date: 2004-02
Authors: Terry L Davidson; Scott E Kanoski; Lindsey A Schier; Deborah J Clegg; Stephen C Benoit Journal: Curr Opin Pharmacol Date: 2007-11-26 Impact factor: 5.547
Authors: Na Yang; Elizabeth Levey; Bizu Gelaye; Qiu-Yue Zhong; Marta B Rondon; Sixto E Sanchez; Michelle A Williams Journal: Arch Womens Ment Health Date: 2017-07-27 Impact factor: 3.633
Authors: Emily E Noble; Charles J Billington; Catherine M Kotz; ChuanFeng Wang Journal: Am J Physiol Regul Integr Comp Physiol Date: 2011-02-23 Impact factor: 3.619
Authors: Christopher Mancuso; Alyssa Izquierdo; Meghan Slattery; Kendra R Becker; Franziska Plessow; Jennifer J Thomas; Kamryn T Eddy; Elizabeth A Lawson; Madhusmita Misra Journal: Psychoneuroendocrinology Date: 2019-12-23 Impact factor: 4.905
Authors: F Bernhard; K Landgraf; N Klöting; A Berthold; P Büttner; D Friebe; W Kiess; P Kovacs; M Blüher; A Körner Journal: Diabetologia Date: 2012-11-16 Impact factor: 10.122