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Literature DB >> 16783567

Cyclin D1 splice variant and risk for non-Hodgkin lymphoma.

Sophia S Wang¹, Wendy Cozen, Richard K Severson, Patricia Hartge, James R Cerhan, Scott Davis, Robert Welch, Nathaniel Rothman, Stephen J Chanock.

Abstract

To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR(AA) = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.

Entities: Disease Gene Mutation

Mesh：

Year: 2006 PMID： 16783567 DOI： 10.1007/s00439-006-0212-3

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

10 in total

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2. Genetic variation and willingness to participate in epidemiologic research: data from three studies.

Authors: Parveen Bhatti; Alice J Sigurdson; Sophia S Wang; Jinbo Chen; Nathaniel Rothman; Patricia Hartge; Andrew W Bergen; Maria Teresa Landi
Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-10 Impact factor: 4.254

3. Cyclin D1 gene polymorphism and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population.

Authors: Xuwei Hou; Sili Wang; Yuling Zhou; Ziliang Xu; Yao Zou; Xiaofan Zhu; Mingzhe Han; Tianxiang Pang; Zhong Chao Han
Journal: Int J Hematol Date: 2005-10 Impact factor: 2.490

Review 4. LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes.

Authors: T H Rabbitts
Journal: Genes Dev Date: 1998-09-01 Impact factor: 11.361

5. The cyclin D1 alternative transcripts [a] and [b] are expressed in normal and malignant lymphocytes and their relative levels are influenced by the polymorphism at codon 241.

Authors: D Howe; C Lynas
Journal: Haematologica Date: 2001-06 Impact factor: 9.941

6. Collection of genomic DNA from adults in epidemiological studies by buccal cytobrush and mouthwash.

Authors: M García-Closas; K M Egan; J Abruzzo; P A Newcomb; L Titus-Ernstoff; T Franklin; P K Bender; J C Beck; L Le Marchand; A Lum; M Alavanja; R B Hayes; J Rutter; K Buetow; L A Brinton; N Rothman
Journal: Cancer Epidemiol Biomarkers Prev Date: 2001-06 Impact factor: 4.254

7. A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma.

Authors: Yawei Zhang; Qing Lan; Nathaniel Rothman; Yong Zhu; Shelia Hoar Zahm; Sophia S Wang; Theodore R Holford; Brian Leaderer; Peter Boyle; Bing Zhang; Kaiyong Zou; Stephen Chanock; Tongzhang Zheng
Journal: J Natl Cancer Inst Date: 2005-11-02 Impact factor: 13.506

8. Risk of non-Hodgkin's lymphoma and family history of lymphatic, hematologic, and other cancers.

Authors: Nilanjan Chatterjee; Patricia Hartge; James R Cerhan; Wendy Cozen; Scott Davis; Naoko Ishibe; Joanne Colt; Lynn Goldin; Richard K Severson
Journal: Cancer Epidemiol Biomarkers Prev Date: 2004-09 Impact factor: 4.254

9. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma.

Authors: Sophia S Wang; Scott Davis; James R Cerhan; Patricia Hartge; Richard K Severson; Wendy Cozen; Qing Lan; Robert Welch; Stephen J Chanock; Nathaniel Rothman
Journal: Carcinogenesis Date: 2006-03-16 Impact factor: 4.944

Review 10. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.

Authors: N L Harris; E S Jaffe; H Stein; P M Banks; J K Chan; M L Cleary; G Delsol; C De Wolf-Peeters; B Falini; K C Gatter
Journal: Blood Date: 1994-09-01 Impact factor: 22.113

10 in total

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2. EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis.

Authors: Rebecca A Mason; Elaine V Morlock; Margaret R Karagas; Karl T Kelsey; Carmen J Marsit; Alan R Schned; Angeline S Andrew
Journal: Carcinogenesis Date: 2009-04-16 Impact factor: 4.944

3. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development.

Authors: Lindsay M Morton; Mark P Purdue; Tongzhang Zheng; Sophia S Wang; Bruce Armstrong; Yawei Zhang; Idan Menashe; Nilanjan Chatterjee; Scott Davis; Qing Lan; Claire M Vajdic; Richard K Severson; Theodore R Holford; Anne Kricker; James R Cerhan; Brian Leaderer; Andrew Grulich; Meredith Yeager; Wendy Cozen; Shelia Hoar Zahm; Stephen J Chanock; Nathaniel Rothman; Patricia Hartge
Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-03-31 Impact factor: 4.254

Review 4. Genetic susceptibility to lymphoma.

Authors: Christine F Skibola; John D Curry; Alexandra Nieters
Journal: Haematologica Date: 2007-07 Impact factor: 9.941