Mary V Jesudason1, S Sivakumar. 1. Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India. micro@cmcvellore.ac.in
Abstract
BACKGROUND & OBJECTIVE: Typhoid fever still continues to be a major public health problem around the world. A simple, reliable and affordable rapid diagnostic test has been a long felt need of the clinicians. We therefore prospectively evaluated the sensitivity and specificity of Typhidot test. METHODS: The study was carried out between January 2002 and December 2003, on a total of 563 samples from patients clinically suspected to have typhoid fever; blood culture as well as serum for Typhidot test were received. RESULTS: Of the 563 samples, Typhidot test and blood culture were positive in 36 patients, both the tests were negative for 503 patients. Typhidot test was positive for 9 patients with S. Paratyphi A infection. The sensitivity and specificity of the test using blood culture as gold standard were 92.3 and 98.8 per cent respectively for the typhoid fever. INTERPRETATION & CONCLUSION: Typhidot test is rapid, easy to perform and reliable test for diagnosing typhoid fever, useful for small less equipped laboratories as well as for those with better facilities.
BACKGROUND & OBJECTIVE:Typhoid fever still continues to be a major public health problem around the world. A simple, reliable and affordable rapid diagnostic test has been a long felt need of the clinicians. We therefore prospectively evaluated the sensitivity and specificity of Typhidot test. METHODS: The study was carried out between January 2002 and December 2003, on a total of 563 samples from patients clinically suspected to have typhoid fever; blood culture as well as serum for Typhidot test were received. RESULTS: Of the 563 samples, Typhidot test and blood culture were positive in 36 patients, both the tests were negative for 503 patients. Typhidot test was positive for 9 patients with S. Paratyphi A infection. The sensitivity and specificity of the test using blood culture as gold standard were 92.3 and 98.8 per cent respectively for the typhoid fever. INTERPRETATION & CONCLUSION: Typhidot test is rapid, easy to perform and reliable test for diagnosing typhoid fever, useful for small less equipped laboratories as well as for those with better facilities.
Authors: Karen H Keddy; Arvinda Sooka; Maupi E Letsoalo; Greta Hoyland; Claire Lise Chaignat; Anne B Morrissey; John A Crump Journal: Bull World Health Organ Date: 2011-06-13 Impact factor: 9.408
Authors: Nur Eliyana Mohd Redhuan; Kai Ling Chin; Azreen Syazril Adnan; Asma Ismail; Prabha Balaram; Kia Kien Phua Journal: J Clin Diagn Res Date: 2017-06-01
Authors: Jason R Andrews; Krishna G Prajapati; Elizabeth Eypper; Poojan Shrestha; Mila Shakya; Kamal R Pathak; Niva Joshi; Priyanka Tiwari; Manisha Risal; Samir Koirala; Abhilasha Karkey; Sabina Dongol; Shawn Wen; Amy B Smith; Duncan Maru; Buddha Basnyat; Stephen Baker; Jeremy Farrar; Edward T Ryan; Elizabeth Hohmann; Amit Arjyal Journal: PLoS Negl Trop Dis Date: 2013-06-27