Literature DB >> 16778986

Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor.

Ole E Sørensen1, Dharma R Thapa, K Markus Roupé, Erika V Valore, Ulf Sjöbring, Alice A Roberts, Artur Schmidtchen, Tomas Ganz.   

Abstract

We found that sterile wounding of human skin induced epidermal expression of the antimicrobial (poly)peptides human beta-defensin-3, neutrophil gelatinase-associated lipocalin, and secretory leukocyte protease inhibitor through activation of the epidermal growth factor receptor. After skin wounding, the receptor was activated by heparin-binding epidermal growth factor that was released by a metalloprotease-dependent mechanism. Activation of the epidermal growth factor receptor generated antimicrobial concentrations of human beta-defensin-3 and increased the activity of organotypic epidermal cultures against Staphylococcus aureus. These data demonstrate that sterile wounding initiates an innate immune response that increases resistance to overt infection and microbial colonization.

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Year:  2006        PMID： 16778986      PMCID： PMC1479426          DOI： 10.1172/JCI28422

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  41 in total

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Review 2.  Understanding the role of immune regulation in wound healing.

Authors:  Julie E Park; Adrian Barbul
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4.  A peptide antibiotic from human skin.

Authors:  J Harder; J Bartels; E Christophers; J M Schröder
Journal:  Nature       Date:  1997-06-26       Impact factor: 49.962

5.  Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils.

Authors:  L Kjeldsen; C Koch; K Arnljots; N Borregaard
Journal:  J Immunol Methods       Date:  1996-11-13       Impact factor: 2.303

6.  Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.

Authors:  T Mitamura; S Higashiyama; N Taniguchi; M Klagsbrun; E Mekada
Journal:  J Biol Chem       Date:  1995-01-20       Impact factor: 5.157

7.  Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.

Authors:  M Marikovsky; K Breuing; P Y Liu; E Eriksson; S Higashiyama; P Farber; J Abraham; M Klagsbrun
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

8.  The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

Authors:  G Sandra Tjabringa; Jamil Aarbiou; Dennis K Ninaber; Jan Wouter Drijfhout; Ole E Sørensen; Niels Borregaard; Klaus F Rabe; Pieter S Hiemstra
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Authors:  Ichiro Nomura; Elena Goleva; Michael D Howell; Quatyba A Hamid; Peck Y Ong; Clifton F Hall; Marc A Darst; Bifeng Gao; Mark Boguniewicz; Jeffrey B Travers; Donald Y M Leung
Journal:  J Immunol       Date:  2003-09-15       Impact factor: 5.422

10.  Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

Authors:  M Zasloff
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205
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  45 in total

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Review 3.  Current insights into the role of human β-defensins in atopic dermatitis.

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4.  Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis.

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Review 6.  Innate and adaptive immune responses against Staphylococcus aureus skin infections.

Authors:  Sheila Krishna; Lloyd S Miller
Journal:  Semin Immunopathol       Date:  2011-11-06       Impact factor: 9.623

7.  Dendritic epidermal T cells regulate skin antimicrobial barrier function.

Authors:  Amanda S MacLeod; Saskia Hemmers; Olivia Garijo; Marianne Chabod; Kerri Mowen; Deborah A Witherden; Wendy L Havran
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8.  Multitasking basal cells: combining stem cell and innate immune duties.

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9.  Gene profiling of narrowband UVB-induced skin injury defines cellular and molecular innate immune responses.

Authors:  Milène Kennedy Crispin; Judilyn Fuentes-Duculan; Nicholas Gulati; Leanne M Johnson-Huang; Tim Lentini; Mary Sullivan-Whalen; Patricia Gilleaudeau; Inna Cueto; Mayte Suárez-Fariñas; Michelle A Lowes; James G Krueger
Journal:  J Invest Dermatol       Date:  2012-11-15       Impact factor: 8.551

10.  Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel.

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