Literature DB >> 16777617

PI3K and RAC signalling in leukocyte and cancer cell migration.

Mark A Barber1, Heidi C E Welch.   

Abstract

Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell migration are phosphoinositide 3-kinase (PI3K) and the Rho family of small GTPases. While PI3K activity defines the leading edge of the cell, Rho family GTPases regulate the cytoskeletal remodelling during polarisation and migration. We review here briefly the roles of PI3K, of the Rho-family GTPase Rac, and of the guanine-nucleotide exchange factors that activate Rac, in leukocyte and cancer cell migration.

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Year:  2006        PMID： 16777617

Source DB:  PubMed          Journal:  Bull Cancer        ISSN： 0007-4551            Impact factor:   1.276


  31 in total

Review 1.  Big roles for small GTPases in the control of directed cell movement.

Authors:  Pascale G Charest; Richard A Firtel
Journal:  Biochem J       Date:  2007-01-15       Impact factor: 3.857

Review 2.  The role of the lens actin cytoskeleton in fiber cell elongation and differentiation.

Authors:  P Vasantha Rao; Rupalatha Maddala
Journal:  Semin Cell Dev Biol       Date:  2006-11-01       Impact factor: 7.727

3.  Myt3 Mediates Laminin-V/Integrin-β1-Induced Islet-Cell Migration via Tgfbi.

Authors:  Bryan R Tennant; Jenny Chen; Alexis Z L Shih; Dan S Luciani; Brad G Hoffman
Journal:  Mol Endocrinol       Date:  2015-07-15

4.  Hyaluronic acid and thrombin upregulate MT1-MMP through PI3K and Rac-1 signaling and prime the homing-related responses of cord blood hematopoietic stem/progenitor cells.

Authors:  Neeta Shirvaikar; Leah A Marquez-Curtis; Mariusz Z Ratajczak; Anna Janowska-Wieczorek
Journal:  Stem Cells Dev       Date:  2010-10-25       Impact factor: 3.272

5.  A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.

Authors:  Zongmeng Li; Haiwei Mou; Ting Wang; Jing Xue; Bo Deng; Lihua Qian; Ye Zhou; Wanghua Gong; Ji Ming Wang; Guohao Wu; Cheng-Fu Zhou; Jing Fang; Yingying Le
Journal:  Cancer Lett       Date:  2012-10-08       Impact factor: 8.679

6.  PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation.

Authors:  Shuyi Nie; Chenbei Chang
Journal:  Mech Dev       Date:  2007-07-19       Impact factor: 1.882

7.  Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway.

Authors:  S Kamura; Y Matsumoto; J-I Fukushi; T Fujiwara; K Iida; Y Okada; Y Iwamoto
Journal:  Br J Cancer       Date:  2010-07-06       Impact factor: 7.640

8.  Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4.

Authors:  Milene Kong; Nicolás Muñoz; Alejandra Valdivia; Alvaro Alvarez; Rodrigo Herrera-Molina; Areli Cárdenas; Pascal Schneider; Keith Burridge; Andrew F G Quest; Lisette Leyton
Journal:  Biochim Biophys Acta       Date:  2013-02-26

9.  p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells.

Authors:  Anna C Cunningham-Edmondson; Steven K Hanks
Journal:  Breast Cancer (Dove Med Press)       Date:  2009-12-07

10.  The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells.

Authors:  Jason S King; Regina Teo; Jonathan Ryves; Jonathan V Reddy; Owen Peters; Ben Orabi; Oliver Hoeller; Robin S B Williams; Adrian J Harwood
Journal:  Dis Model Mech       Date:  2009-04-21       Impact factor: 5.758
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