Literature DB >> 16775095

End points in clinical trials: are they moving the goalposts?

D Y Leung, J K French.   

Abstract

In selecting and defining composite end points in clinical trials, are we trading off clinical significance for statistical significance?

Mesh：

Year:  2006        PMID： 16775095      PMCID： PMC1860712          DOI： 10.1136/hrt.2005.082024

Source DB:  PubMed          Journal:  Heart        ISSN： 1355-6037            Impact factor:   5.994


  10 in total

1.  Absolute, attributable, and relative risk in the management of coronary heart disease.

Authors:  J E Sedgwick
Journal:  Heart       Date:  2001-05       Impact factor: 5.994

Review 2.  Clinical implications of the new definition of myocardial infarction.

Authors:  John K French; Harvey D White
Journal:  Heart       Date:  2004-01       Impact factor: 5.994

3.  Creatine kinase-MB elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes.

Authors:  M T Roe; K W Mahaffey; R Kilaru; J H Alexander; K M Akkerhuis; M L Simoons; R A Harrington; B E Tardiff; C B Granger; E M Ohman; D J Moliterno; A M Lincoff; P W Armstrong; F Van de Werf; R M Califf; E J Topol
Journal:  Eur Heart J       Date:  2004-02       Impact factor: 29.983

4.  Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different?

Authors:  K Martijn Akkerhuis; John H Alexander; Barbara E Tardiff; Eric Boersma; Robert A Harrington; A Michael Lincoff; Maarten L Simoons
Journal:  Circulation       Date:  2002-02-05       Impact factor: 29.690

5.  Incidence, predictors, and significance of abnormal cardiac enzyme rise in patients treated with bypass surgery in the arterial revascularization therapies study (ARTS).

Authors:  M A Costa; R G Carere; S V Lichtenstein; D P Foley; V de Valk; W Lindenboom; P C Roose; T R van Geldorp; C Macaya; J L Castanon; F Fernandez-Avilèz; J H Gonzáles; G Heyer; F Unger; P W Serruys
Journal:  Circulation       Date:  2001-11-27       Impact factor: 29.690

6.  Clinical end point definitions after percutaneous coronary intervention and their relationship to late mortality: an assessment by attributable risk.

Authors:  D P Chew; D L Bhatt; A M Lincoff; K Wolski; E J Topol
Journal:  Heart       Date:  2005-12-30       Impact factor: 5.994

7.  Increased mortality after coronary artery bypass graft surgery is associated with increased levels of postoperative creatine kinase-myocardial band isoenzyme release: results from the GUARDIAN trial.

Authors:  K Klatte; B R Chaitman; P Theroux; J A Gavard; K Stocke; S Boyce; C Bartels; B Keller; A Jessel
Journal:  J Am Coll Cardiol       Date:  2001-10       Impact factor: 24.094

8.  Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial. Randomized Intervention Trial of unstable Angina.

Authors:  K A A Fox; P A Poole-Wilson; R A Henderson; T C Clayton; D A Chamberlain; T R D Shaw; D J Wheatley; S J Pocock
Journal:  Lancet       Date:  2002-09-07       Impact factor: 79.321

9.  Long-term efficacy of bivalirudin and provisional glycoprotein IIb/IIIa blockade vs heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary revascularization: REPLACE-2 randomized trial.

Authors:  A Michael Lincoff; Neal S Kleiman; Dean J Kereiakes; Frederick Feit; John A Bittl; J Daniel Jackman; Ian J Sarembock; David J Cohen; Douglas Spriggs; Ramin Ebrahimi; Gadi Keren; Jeffrey Carr; Eric A Cohen; Amadeo Betriu; Walter Desmet; Wolfgang Rutsch; Robert G Wilcox; Pim J de Feyter; Alec Vahanian; Eric J Topol
Journal:  JAMA       Date:  2004-08-11       Impact factor: 56.272

10.  Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.

Authors: 
Journal:  Lancet       Date:  1988-08-13       Impact factor: 79.321
  10 in total
  1 in total

1.  Varying definitions for periprocedural myocardial infarction alter event rates and prognostic implications.

Authors:  Hanan Idris; Sidney Lo; Ibrahim M Shugman; Yousef Saad; Andrew P Hopkins; Christian Mussap; Dominic Leung; Liza Thomas; Craig P Juergens; John K French
Journal:  J Am Heart Assoc       Date:  2014-10-30       Impact factor: 5.501
  1 in total

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