Literature DB >> 16774229

1,3-diketones from acid chlorides and ketones: a rapid and general one-pot synthesis of pyrazoles.

Stephen T Heller1, Swaminathan R Natarajan.   

Abstract

[reaction: see text] 1,3-Diketones were synthesized directly from ketones and acid chlorides and were then converted in situ into pyrazoles by the addition of hydrazine. This method is extremely fast, general, and chemoselective, allowing for the synthesis of previously inaccessible pyrazoles and synthetically demanding pyrazole-containing fused rings.

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Year:  2006        PMID： 16774229     DOI： 10.1021/ol060570p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  17 in total

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3.  Copper-promoted cycloaddition of diazocarbonyl compounds and acetylides.

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4.  Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.

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6.  Antimicrobial screening to molecular docking of newly synthesized ferrocenyl-substituted pyrazole.

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7.  Leveraging the Knorr Pyrazole Synthesis for the Facile Generation of Thioester Surrogates for use in Native Chemical Ligation.

Authors:  Dillon T Flood; Jordi C J Hintzen; Michael J Bird; Philip A Cistrone; Jason S Chen; Philip E Dawson
Journal:  Angew Chem Int Ed Engl       Date:  2018-08-10       Impact factor: 15.336

8.  C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition.

Authors:  Roman Goikhman; Teresa L Jacques; Dalibor Sames
Journal:  J Am Chem Soc       Date:  2009-03-04       Impact factor: 15.419

9.  Multicomponent Pyrazole Synthesis from Alkynes, Nitriles, and Titanium Imido Complexes via Oxidatively Induced N-N Bond Coupling.

Authors:  Adam J Pearce; Robin P Harkins; Benjamin R Reiner; Alexander C Wotal; Rachel J Dunscomb; Ian A Tonks
Journal:  J Am Chem Soc       Date:  2020-02-20       Impact factor: 15.419

10.  3-(4-Chloro-anilino)-5,5-dimethyl-cyclo-hex-2-en-1-one.

Authors:  Sumati Anthal; Ambika Sambyal; R K Bamzai; Rajni Kant; Vivek K Gupta
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-14
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