OBJECTIVE: To evaluate retinal anatomy using ultrahigh-resolution optical coherence tomography (OCT) in eyes after successful surgical repair of full-thickness macular hole. METHODS: Twenty-two eyes of 22 patients were diagnosed as having macular hole, underwent pars plana vitrectomy, and had flat/closed macular anatomy after surgery, as confirmed with biomicroscopic and OCT examination findings. An ultrahigh-resolution-OCT system developed for retinal imaging, with the capability to achieve approximately 3-microm axial resolution, was used to evaluate retinal anatomy after hole repair. RESULTS: Despite successful closure of the macular hole, all 22 eyes had macular abnormalities on ultrahigh-resolution-OCT images after surgery. These abnormalities were separated into the following 5 categories: (1) outer foveal defects in 14 eyes (64%), (2) persistent foveal detachment in 4 (18%), (3) moderately reflective foveal lesions in 12 (55%), (4) epiretinal membranes in 14 (64%), and (5) nerve fiber layer defects in 3 (14%). CONCLUSIONS: With improved visualization of fine retinal architectural features, ultrahigh-resolution OCT can visualize persistent retinal abnormalities despite anatomically successful macular hole surgery. Outer foveal hyporeflective disruptions of the junction between the inner and outer segments of the photoreceptors likely represent areas of foveal photoreceptor degeneration. Moderately reflective lesions likely represent glial cell proliferation at the site of hole reapproximation. Thin epiretinal membranes do not seem to decrease visual acuity and may play a role in reestablishing foveal anatomy after surgery.
OBJECTIVE: To evaluate retinal anatomy using ultrahigh-resolution optical coherence tomography (OCT) in eyes after successful surgical repair of full-thickness macular hole. METHODS: Twenty-two eyes of 22 patients were diagnosed as having macular hole, underwent pars plana vitrectomy, and had flat/closed macular anatomy after surgery, as confirmed with biomicroscopic and OCT examination findings. An ultrahigh-resolution-OCT system developed for retinal imaging, with the capability to achieve approximately 3-microm axial resolution, was used to evaluate retinal anatomy after hole repair. RESULTS: Despite successful closure of the macular hole, all 22 eyes had macular abnormalities on ultrahigh-resolution-OCT images after surgery. These abnormalities were separated into the following 5 categories: (1) outer foveal defects in 14 eyes (64%), (2) persistent foveal detachment in 4 (18%), (3) moderately reflective foveal lesions in 12 (55%), (4) epiretinal membranes in 14 (64%), and (5) nerve fiber layer defects in 3 (14%). CONCLUSIONS: With improved visualization of fine retinal architectural features, ultrahigh-resolution OCT can visualize persistent retinal abnormalities despite anatomically successful macular hole surgery. Outer foveal hyporeflective disruptions of the junction between the inner and outer segments of the photoreceptors likely represent areas of foveal photoreceptor degeneration. Moderately reflective lesions likely represent glial cell proliferation at the site of hole reapproximation. Thin epiretinal membranes do not seem to decrease visual acuity and may play a role in reestablishing foveal anatomy after surgery.
Authors: Michael N Apostolopoulos; Chryssanthi N Koutsandrea; Michael N Moschos; Dimitrios A Alonistiotis; Alexis E Papaspyrou; John A Mallias; Theodora E Kyriaki; Panagiotis G Theodossiadis; George P Theodossiadis Journal: Am J Ophthalmol Date: 2002-11 Impact factor: 5.258
Authors: Elisabeth M Anger; Angelika Unterhuber; Boris Hermann; Harald Sattmann; Christian Schubert; James E Morgan; Alan Cowey; Peter K Ahnelt; Wolfgang Drexler Journal: Exp Eye Res Date: 2004-06 Impact factor: 3.467
Authors: Christos Haritoglou; Carolin A Gass; Markus Schaumberger; Arnd Gandorfer; Michael W Ulbig; Anselm Kampik Journal: Am J Ophthalmol Date: 2002-11 Impact factor: 5.258
Authors: W E Benson; K C Cruickshanks; D S Fong; G A Williams; M A Bloome; D A Frambach; A E Kreiger; R P Murphy Journal: Ophthalmology Date: 2001-07 Impact factor: 12.079
Authors: José Maria Ruiz-Moreno; Francisco Lugo; Javier A Montero; David P Piñero Journal: Graefes Arch Clin Exp Ophthalmol Date: 2012-02-23 Impact factor: 3.117