| Literature DB >> 16769097 |
Sheng-Jun Dai1, Jia-Yi Tao, Ke Liu, Yong-Tao Jiang, Li Shen.
Abstract
Three neo-clerodane diterpenoids, named barbatins A-C (1-3), and the neo-clerodane diterpenoid nicotinyl ester, named scutebarbatine B (4), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic analyses (UV, IR, HRFAB-MS, 1D NMR and 2D NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC50 values in the range 3.5-8.1 microM.Entities:
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Year: 2006 PMID： 16769097 DOI： 10.1016/j.phytochem.2006.04.024
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072